Respiratory Research
EBC studies that have used the RTube™
This research index highlights recent exhaled breath condensate (EBC) studies that used the RTube breath condensate collection device in clinical trials, occupational, environmental, and respiratory biomarker research and monitoring. The studies below cover major areas of breath condensate analysis, including airway inflammation, oxidative stress biomarkers, lung disease diagnostics, COPD research, asthma studies, lung cancer breath testing, breathomics, metabolomics, proteomics, and noninvasive pulmonary monitoring.
2025
1. Highly sensitive multiplex assay of interleukins in exhaled breath condensate from children with bronchial asthma: diagnostic significance of IL-13 and IL-17A
Methods / analytical study
Citation: Smolnikova, M. V., Gorbacheva, N. N., et al. (2025). Highly sensitive multiplex assay of interleukins in exhaled breath condensate from children with bronchial asthma: Diagnostic significance of IL-13 and IL-17A. Russian Journal of Immunology. Citation link
RTube use: EBC was collected with the RTube device from children with bronchial asthma; samples were concentrated and assayed for interleukins, with IL-13 and IL-17A evaluated as asthma-related inflammatory markers.
Study focus: Pediatric asthma biomarker study using RTube-collected condensate for multiplex cytokine profiling.
2. Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19
Research study
Citation: Gade, I. L., Bodilsen, J., Mariager, T., Hertz, S., et al. (2025). Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19. Journal of Breath Research. Citation link
RTube use: RTubes were used to collect EBC from 28 hospitalized COVID-19 patients at admission and discharge; condensate proteins were analyzed by bottom-up proteomics.
Study focus: COVID-19 respiratory proteomics using serial RTube EBC sampling.
3. Volatile organic compound and proteomics data from the same exhaled breath condensate sample
Dataset / data article
Citation: Schrader, S. E., Hansen, J. R., O’Bryon, I., et al. (2025). Volatile organic compound and proteomics data from the same exhaled breath condensate sample. Journal of Breath Research. Citation link
RTube use: The study used the RTube for EBC capture and incorporated RTube water blanks as negative controls, pushing water through and sloshing it within the collection chamber to quantify device/background contribution.
Study focus: Method/data study showing combined VOC and proteomic measurement from the same RTube-collected condensate sample.
4. Pentadecanoic acid attenuates pulmonary fibrosis by inhibiting Smad2/3 signaling
Research study
Citation: Kim, Y., Han, Y., Jeon, G. S., Song, J. W., et al. (2025). Pentadecanoic acid attenuates pulmonary fibrosis by inhibiting Smad2/3 signaling. American Journal of Respiratory and Critical Care Medicine. Citation link
RTube use: EBC from patients with idiopathic pulmonary fibrosis was collected using the RTube condenser and analyzed for C15:0/pentadecanoic-acid-associated signals.
Study focus: Pulmonary fibrosis biomarker/mechanism study linking RTube EBC metabolite measurements to fibrotic signaling biology.
5. Fuel-Free Rolosense: Viral sensing using diffusional particle tracking
Research study
Citation: Piranej, S., Jackson, K., Zhang, L., Kæstel-Hansen, J., et al. (2025). Fuel-Free Rolosense: Viral sensing using diffusional particle tracking. ACS Publications. Citation link
RTube use: The RTube breath condensate collection device was purchased from Respiratory Research and used as the EBC sampling platform for testing viral-sensing assay behavior in breath condensate.
Study focus: Analytical biosensor study using RTube-collected breath condensate as a biological matrix for viral detection.
6. The detection of cannabinoids in breath after ingestion of cannabis-infused edibles
Conference abstract
Citation: Berry, J. L., Brooks-Russell, A., et al. (2025). The detection of cannabinoids in breath after ingestion of cannabis-infused edibles. Journal of Analytical Toxicology. Citation link
RTube use: A participant subset used an RTube condensate device to collect exhaled breath aerosols/EBC after edible cannabis ingestion; THC and related cannabinoids were assessed in the breath matrix.
Study focus: Forensic/toxicology study testing whether RTube EBC can capture cannabinoids after oral cannabis exposure.
7. A handheld biofluorometric system for acetone detection in exhaled breath condensates
Methods / analytical study
Citation: Zhang, G., Ichikawa, K., Iitani, K., Iwasaki, Y., et al. (2025). A handheld biofluorometric system for acetone detection in exhaled breath condensates. Analyst. Citation link
RTube use: Healthy participants collected EBC using an RTube after maintaining constant breathing for 8 minutes while sedentary; the condensate was tested with a handheld biofluorometric acetone system.
Study focus: Point-of-care analytical chemistry study using RTube EBC to measure acetone in breath condensate.
8. Linking volatile metabolites from bacterial pathogens to exhaled breath condensate of people with cystic fibrosis
Research study
Citation: Karunarathne, P. H., Bridges, C., Remisoski, L., et al. (2025). Linking volatile metabolites from bacterial pathogens to exhaled breath condensate of people with cystic fibrosis. Microbiology Research. Citation link
RTube use: EBC was collected through an RTube with an added filter/mouthpiece configuration; after clearing the device, condensate volumes ranged roughly from 500 μL upward for downstream volatile-metabolite comparisons.
Study focus: Cystic fibrosis breathomics study connecting pathogen-derived volatile metabolites with RTube EBC profiles.
9. Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells
Research study
Citation: Pedklang, N., Navasumrit, P., Chompoobut, C., et al. (2025). Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells. International Journal of Hygiene and Environmental Health. Citation link
RTube use: Human EBC was collected as the noninvasive airway matrix for measuring DNA damage and mitochondrial/telomere-related endpoints associated with traffic-related particulate exposure; indexed RTube usage identifies the collection platform.
Study focus: Environmental exposure study using breath condensate genomics markers to assess particulate-pollution effects.
10. The role of myristic acid in the pathogenesis of pulmonary fibrosis
Research study
Citation: Han, Y. J., Kim, Y., Jeon, G. S., Song, J. W., et al. (2025). The role of myristic acid in the pathogenesis of pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. Citation link
RTube use: EBC samples from pulmonary fibrosis patients were collected using the RTube condenser and analyzed for myristic-acid-related metabolite signals.
Study focus: Pulmonary fibrosis metabolite study using RTube EBC to connect fatty-acid signatures with disease pathogenesis.
11. Occupational exposure to aerosols in two French airports: multi-year lung function changes
Conference abstract
Citation: Touri, L., Tarantini, A., Suehs, C. E., Nogué, E., et al. (2025). Occupational exposure to aerosols in two French airports: Multi-year lung function changes. Annals of Work Exposures and Health. Citation link
RTube use: EBC from airport workers was collected into RTubes and immediately frozen at −20 °C in the collecting portions of the devices for later exposure/biomarker analysis.
Study focus: Occupational aerosol exposure study linking airport-worker exposures, lung function, and RTube EBC biomarkers.
2024
12. Exhaled breath condensate contains extracellular vesicles that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed
Research study
Citation: Mitchell, M. I., Ben-Dov, I. Z., Ye, K., Liu, C., et al. (2024). Exhaled breath condensate contains extracellular vesicles that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed. Journal of Extracellular Vesicles. Citation link
RTube use: The authors evaluated whether EBC collected with the RTube device allowed condensation and recovery of exhaled extracellular vesicles, then selectively purified and analyzed miRNA cargo.
Study focus: Extracellular-vesicle and miRNA method study validating RTube EBC as a source of lung-origin vesicular biomarkers.
13. Measurement of human and bovine exhaled breath condensate pH using polyaniline-modified flexible inkjet-printed nanocarbon electrodes
Methods / analytical study
Citation: Jacobs, A. I., Prete, M. C., Lesch, A., Sebio, A. A., et al. (2024). Measurement of human and bovine exhaled breath condensate pH using polyaniline-modified flexible inkjet-printed nanocarbon electrodes. ACS Omega, 9(39), 40841–40856. https://doi.org/10.1021/acsomega.4c05800 Citation link
RTube use: An RTube device was used for human EBC collection, while a modified collection arrangement was used for bovine breath condensate; pH was measured with flexible inkjet-printed carbon electrodes.
Study focus: Electrochemical sensor study using RTube human EBC for pH measurement and cross-species comparison.
14. A pilot study to detect inflammatory biomarkers of pneumonitis in exhaled breath during chemoradiotherapy for stage III non-small cell lung cancer
Conference abstract
Citation: Hughes, R. T., Reno, K. E., Levine, B., Bishop, A. C., et al. (2024). A pilot study to detect inflammatory biomarkers of pneumonitis in exhaled breath during chemoradiotherapy for stage III non-small cell lung cancer. International Journal of Radiation Oncology Biology Physics. Citation link
RTube use: EBC and serum were collected at baseline, two weeks, six weeks, and one month post-chemoradiotherapy; EBC was collected using the RTube device to monitor inflammatory biomarkers.
Study focus: Cancer-therapy toxicity pilot study using repeated RTube EBC sampling to detect pneumonitis-associated inflammation.
15. Extraction and characterization of exosomes from the exhaled breath condensate and sputum of lung cancer patients and vulnerable tobacco consumers
Research study
Citation: Bano, A., Yadav, P., Sharma, M., Verma, D., et al. (2024). Extraction and characterization of exosomes from the exhaled breath condensate and sputum of lung cancer patients and vulnerable tobacco consumers. Journal of Breath Research. Citation link
RTube use: Approximately 320 μL of EBC collected from RTUBE was centrifuged and processed with exosome isolation reagent to characterize exosomal material in lung cancer and tobacco-exposed participants.
Study focus: Lung-cancer exosome study using RTube EBC as a noninvasive liquid-biopsy matrix.
16. Cannabinoids detected in exhaled breath condensate after cannabis use
Research study
Citation: Berry, J. L., Brooks-Russell, A., Beuning, C. N., et al. (2024). Cannabinoids detected in exhaled breath condensate after cannabis use. Journal of Breath Research. Citation link
RTube use: The study collected EBC as an aqueous breath matrix containing condensed volatile compounds and aerosols, using RTube-based condensate capture to test cannabinoid detection after cannabis use.
Study focus: Breath toxicology study evaluating cannabinoids in RTube-collected EBC.
17. Development and validation of a method for analysis of 25 cannabinoids in oral fluid and exhaled breath condensate
Methods / analytical study
Citation: Swaminathan, M., Tarifa, A., & DeCaprio, A. P. (2024). Development and validation of a method for analysis of 25 cannabinoids in oral fluid and exhaled breath condensate. Analytical and Bioanalytical Chemistry. Citation link
RTube use: Participants breathed into a chilled disposable plastic RTube for 5–10 minutes; the sleeve was positioned over the RTube and condensate was recovered for cannabinoid method validation.
Study focus: Analytical method validation for cannabinoid measurement in RTube-collected EBC.
18. Exhaled Breath Condensate Surveillance for Aspergillus in Acute Leukemia: A Pilot Trial
Conference abstract
Citation: Bitterman, R., Arora, S., Ng, C. F., Walti, L., et al. (2024). Exhaled breath condensate surveillance for Aspergillus in acute leukemia: A pilot trial. Open Forum Infectious Diseases. Citation link
RTube use: The study evaluated Aspergillus droplet-digital PCR in EBC for leukemia patients; the Respiratory Research index places the work within the RTube EBC corpus, with collection used as the noninvasive airway surveillance matrix.
Study focus: Pilot fungal surveillance study testing EBC as a screening sample for Aspergillus in immunocompromised patients.
19. The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study
Research study
Citation: Gu, S. Y., Lu, H. W., Bai, J. W., Yang, J. W., Mao, B., Yu, L., et al. (2024). The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: An observational study. Frontiers in Medicine. Citation link
RTube use: Disposable RTube exhaled breath condensate collectors were used to minimize cross-contamination and infectious risk while collecting breath samples for VOC-related bronchiectasis assessment.
Study focus: Bronchiectasis breathomics study using RTube collectors to relate VOC/EBC signatures to disease features.
20. A Clinical Breathomics Dataset
Dataset / data article
Citation: Kuo, P. H., Jhong, Y. C., Kuo, T. C., Hsu, Y. T., Kuo, C. H., et al. (2024). A clinical breathomics dataset. Scientific Data. https://doi.org/10.1038/s41597-024-03052-2 Citation link
RTube use: Healthy individuals fasted for 8 hours; the RTube aluminum sleeve was precooled at −80 °C for 20 minutes, subjects breathed tidally for 15 minutes, and EBC samples were immediately stored at −80 °C.
Study focus: Open breathomics dataset using standardized RTube EBC collection for metabolomics-method development and QC.
21. Effects of E-cigarettes on the lung and systemic metabolome in people with HIV
Research study
Citation: Zaparte, A., Christopher, C. J., Arnold, C., Richey, L., et al. (2024). Effects of e-cigarettes on the lung and systemic metabolome in people with HIV. Metabolites, 14, 434. Citation link
RTube use: Participants breathed normally through a cooled RTube to collect EBC; condensate was analyzed with oral and stool metabolomes to assess vaping-associated metabolic changes in people with HIV.
Study focus: Human metabolomics study using RTube EBC to examine e-cigarette effects on lung-associated metabolites.
22. Roles of inflammatory biomarkers in exhaled breath condensates in respiratory clinical fields
Research study
Citation: Choi, Y. J., Lee, M. J., Byun, M. K., Park, S., Park, J., et al. (2024). Roles of inflammatory biomarkers in exhaled breath condensates in respiratory clinical fields. Tuberculosis and Respiratory Diseases. Citation link
RTube use: Subjects breathed through the RTube mouthpiece and condensate was pushed into the cap with the plunger; EBC inflammatory biomarkers were measured across respiratory clinical contexts.
Study focus: Clinical respiratory biomarker study using standardized RTube EBC handling for inflammatory-marker analysis.
23. Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study
Protocol / study designAppended client-supplied record
Citation: JL Curtis, LA Bateman, S Murray… - … : Journal of the …, 2024 - pmc.ncbi.nlm.nih.gov. Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study. Citation link
RTube use: Exhaled breath condensate (EBC) is collected only at baseline using the RTube (… assessments involving blood, exhaled breath condensate, sputum, and bronchoscopy samples. We
Study focus: Protocol / study design involving RTube/EBC product use as represented in the linked source excerpt.
24. Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor
Methods / analytical studyAppended client-supplied record
Citation: S Piranej, L Zhang, A Bazrafshan, M Marin… - ACS Central …, 2024 - ACS Publications. Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor. Citation link
RTube use: Our results indicate that breath condensate did not affect the robustness of our assay, as … RTube breath condensate collection device was purchased from Respiratory Research (nos
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
25. Effects of E-Cigarettes on the Lung and Systemic Metabolome in People with HIV. Metabolites 2024, 14, 434
Research studyAppended client-supplied record
Citation: A Zaparte, CJ Christopher, C Arnold,L Richey… - 2024 - digitalscholar.lsuhsc.edu. Effects of E-Cigarettes on the Lung and Systemic Metabolome in People with HIV. Metabolites 2024, 14, 434. Citation link
RTube use: changes caused by cigarette smoke condensate [22]. Vaping … breath condensate (EBC), oral, and stool metabolomes as … Briefly, participants breath normally though a cooled RTube™
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2023
26. A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism
Research study
Citation: Gade, I. L., Riddersholm, S. J., et al. (2023). A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism. Journal of Breath Research. Citation link
RTube use: The RTube aluminum sleeve was precooled to −80 °C, transported on dry ice, covered with insulation during collection, and used to collect EBC for proteomic pulmonary embolism biomarker discovery.
Study focus: Clinical pulmonary embolism proteomics study using chilled RTube condensate collection.
27. MEASURE: Multiplex Exhaled Breath Condensate — Scanning Using Rapid Electro-Analytics
Research study
Citation: Bhide, A., Eldeeb, M. A., Pali, M., Muthukumar, S., & Prasad, S. (2023). MEASURE: Multiplex exhaled breath condensate — scanning using rapid electro-analytics. ACS Sensors, 8(9), 3408–3416. https://doi.org/10.1021/acssensors.3c00693 Citation link
RTube use: Disposable RTube collector tubes procured from Respiratory Research were used to collect EBC for a multiplex electrochemical assay targeting inflammatory biomarkers.
Study focus: Point-of-care sensor platform study using RTube EBC for rapid multiplex biomarker measurement.
28. Stable COPD picture through exhaled breath condensate, questionnaires and tests: A proof of concept study
Research study
Citation: Patsiris, S., Afthinos, A., Augouste, L., Valsami, K., et al. (2023). Stable COPD picture through exhaled breath condensate, questionnaires and tests: A proof of concept study. Pulmonology and Respiratory Journal. Citation link
RTube use: EBC was collected with the RTube and analyzed with an Accusizer/FxNano particle counter to relate condensate particle concentration to stable COPD assessment.
Study focus: COPD proof-of-concept study linking RTube EBC particle measurements with clinical questionnaires and tests.
29. Metabolomic analysis identifies differences in energy metabolism in exhaled breath condensate from patients with radiation-induced lung fibrosis
Conference abstract
Citation: Pierre-Louis, J., Freeberg, M. A. T., Camus, S. V., et al. (2023). Metabolomic analysis identifies differences in energy metabolism in exhaled breath condensate from patients with radiation-induced lung fibrosis. American Thoracic Society Abstracts. Citation link
RTube use: EBC was collected with the RTube as a natural respiratory-tract matrix and analyzed metabolomically to evaluate energy-metabolism differences in radiation-induced lung fibrosis.
Study focus: Radiation-induced lung fibrosis metabolomics study using RTube EBC.
30. Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination
Methods / analytical study
Citation: Shi, M., Han, W., Loudig, O., Shah, C. D., Dobkin, J. B., et al. (2023). Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Scientific Reports, 13, 6620. https://doi.org/10.1038/s41598-023-33698-8 Citation link
RTube use: Seated subjects were equipped with the RTube system before clinically indicated procedures; condensate was recovered from the device and interrogated by qualitative RT-PCR for a lung-cancer-associated microRNA panel.
Study focus: Case-control lung cancer liquid-biopsy study using RTube EBC microRNA detection.
31. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia
Research study
Citation: Course, C. W., Lewis, P. A., Kotecha, S. J., Cousins, M., et al. (2023). Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports. Citation link
RTube use: Children underwent respiratory testing with EBC collection using RTube®, and the condensate proteome was characterized before/after inhaler therapy.
Study focus: Pediatric BPD proteomics study using RTube EBC to measure airway protein changes linked to treatment.
32. Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Methods / analytical study
Citation: Rubio, K., Müller, J. M., Mehta, A., Watermann, I., Olchers, T., et al. (2023). Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score. Discover Oncology. Citation link
RTube use: Exhaled breath condensates were collected with an RTube device according to Respiratory Research protocols and analyzed for molecular loci contributing to the LC score.
Study focus: Early lung cancer detection study using RTube EBC for molecular marker scoring.
33. Evidence of abnormality in glutathione metabolism in the airways of preterm-born children with a history of bronchopulmonary dysplasia
Research study
Citation: Course, C. W., Lewis, P. A., Kotecha, S. J., Cousins, M., et al. (2023). Evidence of abnormality in glutathione metabolism in the airways of preterm-born children with a history of bronchopulmonary dysplasia. Scientific Reports. Citation link
RTube use: EBC was collected in a standardized manner using an RTube cooling tube and then subjected to metabolomic analysis focused on glutathione-related airway metabolism.
Study focus: Pediatric BPD metabolomics study using RTube EBC to identify oxidative-stress/metabolic abnormalities.
34. Bacterial microbiota differences in the respiratory tract of children with bronchial asthma
Research study
Citation: Bar, K. (2023). Bacterial microbiota differences in the respiratory tract of children with bronchial asthma. Medical University repository. Citation link
RTube use: Exhaled breath condensate was collected with the RTube kit and compared with other airway samples to assess bacterial microbiota patterns in children with asthma.
Study focus: Pediatric asthma microbiome study using RTube EBC as a low-biomass respiratory sample.
35. Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women
Research studyAppended client-supplied record
Citation: JRJR STENCZER, G LOSONCZY, I HORVÁTH… - academia.edu. Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women. Citation link
RTube use: Condensate samples were collected for 10 min using a handheld device (RTube, … The chiller tube was held at À80C before condensate collection. Samples were stored at À80C in
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
36. The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and …
Research studyAppended client-supplied record
Citation: N Drabińska, J Romaszko, P White - Plos one, 2023 - journals.plos.org. The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and …. Citation link
RTube use: Exhaled breath condensate samples will be collected using commercial sampling tubes (RTubes), which allow for the collection of approx. 3 mL condensate within 10 minutes. All the
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2022
37. A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection
Methods / analytical study
Citation: Mosquera-Restrepo, S. F., Zuberogoïtia, S., Nigou, J., et al. (2022). A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection. Nature Communications, 13. Citation link
RTube use: EBCs were collected using R-tubes from Respiratory Research; the device was used as a noninvasive system to collect and condense expiration components for tuberculosis detection.
Study focus: Tuberculosis diagnostic study using RTube EBC to identify breath-based mycobacterial signatures.
38. Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages
Research study
Citation: Marie-Desvergne, C., Dubosson, M., et al. (2022). Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages. Journal of Breath Research. Citation link
RTube use: RTubes were washed and validated with blank RTubes filled with ultrapure water after washing; patient EBC elemental/particle loads were compared with pulmonary lavage samples.
Study focus: Method-comparison study evaluating RTube EBC particle/element content against invasive respiratory samples.
39. Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide
Methods / analytical study
Citation: Gholizadeh, A., Black, K., Kipen, H., Laumbach, R., Gow, A., et al. (2022). Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide. RSC Advances. Citation link
RTube use: EBC was collected using RTube and Jaeger EcoScreen systems; RTube samples were partitioned for immediate analysis or frozen storage, then tested using reduced graphene oxide sensors.
Study focus: Sensor-development study using RTube EBC for nonprocessed inflammatory-biomarker detection.
40. The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma
Research study
Citation: Malinchik, M. A., Gorbacheva, N. N., Belenjuk, V. D., et al. (2022). The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma. Siberian Medical Review. Citation link
RTube use: EBC was collected with the RTube Exhaled Breath Condensate Collector and cytokine concentrations were measured in native condensate samples.
Study focus: Pediatric asthma study linking RTube EBC cytokines with cytokine gene polymorphisms.
41. Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis
Research study
Citation: Wei, S., Chen, Y.-S., & Shi, Y. (2022). Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis. Frontiers in Cellular and Infection Microbiology, 12, 1008924. https://doi.org/10.3389/fcimb.2022.1008924 Citation link
RTube use: EBC was collected with a commercially available RTube condenser from Respiratory Research; typical adult tidal-breathing collection was 7–10 minutes, aiming for at least 1000 μL condensate for metabolomic analysis.
Study focus: Pulmonary aspergillosis diagnostic metabolomics study using RTube EBC.
42. A pilot study of total personal exposure to volatile organic compounds among Hispanic female domestic cleaners
Research study
Citation: Oyer-Peterson, K., et al. (2022). A pilot study of total personal exposure to volatile organic compounds among Hispanic female domestic cleaners. Journal of Occupational and Environmental Hygiene. Citation link
RTube use: Participants provided EBC samples in labeled RTubes, which were used alongside badges and blood sampling to assess personal VOC exposure.
Study focus: Occupational exposure pilot study using RTube EBC as one biological matrix for VOC-related biomonitoring.
43. EBC-SURE: Exhaled Breath Condensate-Scanning Using Rapid Electro-Analytics
Methods / analytical study
Citation: Bhide, A., Pali, M., Muthukumar, S., & Prasad, S. (2022). EBC-SURE: A non-faradaic and non-invasive electrochemical assay to screen for pro-inflammatory biomarkers in exhaled breath condensate. Biosensors and Bioelectronics. Citation link
RTube use: Human EBC was collected and analyzed on the EBC-SURE electrochemical platform for trace detection of IL-6 and hs-CRP, with RTube collection identified in the RTube research corpus.
Study focus: Electrochemical point-of-care assay study using EBC for inflammatory biomarker screening.
44. Physical training reduces chronic airway inflammation and mediators of remodeling in asthma
Research study
Citation: Moraes-Ferreira, R., Brandão-Rangel, M. A. R., et al. (2022). Physical training reduces chronic airway inflammation and mediators of remodeling in asthma. Oxidative Medicine and Cellular Longevity. Citation link
RTube use: EBC collection was performed through the RTube; patients breathed into the RTube before downstream assessment of airway inflammation and remodeling mediators.
Study focus: Asthma intervention study using RTube EBC to track training-related airway inflammatory changes.
45. Exhaled eicosanoid metabolomics suggest oxidized lipids/eicosanoids are detectable in lung cancer cases
Conference abstract
Citation: Spivack, S. D., Shi, M., Sadoughi, A., Shah, C., et al. (2022). Exhaled eicosanoid metabolomics suggest oxidized lipids/eicosanoids are detectable in lung cancer cases. American Thoracic Society Abstracts. Citation link
RTube use: Clinical subjects performed approximately 15 minutes of tidal breathing to collect about 1.0 mL EBC in the RTube for downstream eicosanoid/oxidized-lipid metabolomics.
Study focus: Lung cancer metabolomics study using RTube EBC for eicosanoid signature discovery.
46. Arginine and its analogs as biomarkers in serum and exhaled breath condensate for diagnosis and monitoring of asthma
Research study
Citation: Połomska, J. (2022). Arginine and its analogs as new biomarkers measured in serum and exhaled breath condensate for diagnosis and monitoring of asthma. Medical University repository. Citation link
RTube use: Exhaled breath condensate was collected using an RTube device and compared with serum measurements of arginine-pathway analytes in asthma diagnosis and monitoring.
Study focus: Asthma biomarker study using RTube EBC for arginine-metabolism analysis.
47. Aerobic training reduces chronic airway inflammation and mediators of remodeling in asthma
Conference abstractAppended client-supplied record
Citation: R Moraes-Ferreira, MAR Brandao-Rangel… - Available at SSRN … - papers.ssrn.com. Aerobic training reduces chronic airway inflammation and mediators of remodeling in asthma. Citation link
RTube use: On the first day, the following evaluations were performed: (i) Exhaled breath condensate collection through the tube RTube (Respiratory Research, USA), in which the patient breathed
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
2021
48. Extracellular vesicle-derived microbiome obtained from exhaled breath condensate in patients with asthma
Research study
Citation: An, J., McDowell, A., Kim, Y. K., & Kim, T. B. (2021). Extracellular vesicle-derived microbiome obtained from exhaled breath condensate in patients with asthma. Annals of Allergy, Asthma & Immunology. Citation link
RTube use: EBC samples were collected using RTube from Respiratory Research; extracellular vesicles were isolated from EBC and 16S rDNA was analyzed.
Study focus: Asthma microbiome study using RTube EBC to characterize extracellular-vesicle-associated bacterial DNA.
49. Use of exhaled breath condensate in the diagnosis of SARS-CoV-2 (COVID-19)
Conference abstract
Citation: Ryan, D. J., Toomey, S., Madden, S. F., Casey, M., et al. (2021). Use of exhaled breath condensate (EBC) in the diagnosis of SARS-CoV-2 (COVID-19). Thorax. Citation link
RTube use: EBC was used as a lower-respiratory-tract sample for SARS-CoV-2 RT-PCR detection; RTube-based collection is identified in the RTube EBC research corpus.
Study focus: COVID-19 diagnostic study testing EBC as a noninvasive sample for viral RNA detection.
50. Putative biomarkers for acute pulmonary embolism in exhaled breath condensate
Research study
Citation: Gade, I. L., Schultz, J. G., Brøndum, R. F., Kjærgaard, B., et al. (2021). Putative biomarkers for acute pulmonary embolism in exhaled breath condensate. Journal of Clinical Medicine. Citation link
RTube use: In a porcine pulmonary embolism model, the RTube was inserted into the expiratory limb of the ventilator circuit to collect EBC for proteomic biomarker discovery.
Study focus: Preclinical pulmonary embolism study using ventilator-adapted RTube EBC collection.
51. Exhaled breath condensate in acute pulmonary embolism: a porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry
Research study
Citation: Gade, I. L., Schultz, J. G., Cehofski, L. J., et al. (2021). Exhaled breath condensate in acute pulmonary embolism: A porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry. Journal of Breath Research. Citation link
RTube use: The study used RTube-based condensate collection in ventilated pigs to test how condensing temperature influenced EBC yield and protein analysis feasibility.
Study focus: Methodological porcine PE study validating RTube EBC for mass-spectrometry proteomics.
52. Prediction of potential passive exposure from commercial electronic nicotine delivery systems using exhaled breath analysis and computational fluid dynamic modeling
Research study
Citation: Oldham, M. J., Bailey, P. C., Castro, N., Lang, Q., et al. (2021). Prediction of potential passive exposure from commercial electronic nicotine delivery systems using exhaled breath analysis and computational fluid dynamic modeling. Journal of Breath Research. Citation link
RTube use: EBC from the RTube and filter samples were extracted for GC/MS analysis of nicotine, propylene glycol, and related ENDS aerosol constituents.
Study focus: E-cigarette exposure study using RTube EBC to characterize passive exposure potential.
53. The differences in oxidative status marker and soluble CD95 in COPD during exacerbation and stable periods
Research study
Citation: Soodaeva, S., Kubysheva, N., Klimanov, I., et al. (2021). Differences in oxidative status marker and soluble CD95 in patients with moderate to severe COPD during exacerbation and stable disease. Oxidative Medicine and Cellular Longevity. Citation link
RTube use: EBC was collected using RTube following ERS/ATS recommendations; oxidative status markers and soluble CD95 were compared in blood and condensate.
Study focus: COPD biomarker study using RTube EBC to assess oxidative and apoptotic/inflammatory markers.
54. The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD
Research study
Citation: Ween, M. P., White, J. B., Tran, H. B., Mukaro, V., Jones, C., et al. (2021). The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD. Scientific Reports. Citation link
RTube use: EBC was collected with a commercial collector following manufacturer instructions, identified as RTube, and used alongside bronchoalveolar lavage to assess oxidized lipid biology.
Study focus: COPD immunometabolism study using RTube EBC as a noninvasive comparator to lavage samples.
55. The health effects of wearing facemasks on cardiopulmonary system of healthy young adults: a double-blinded randomized crossover trial
Research study
Citation: Jiang, M., Meng, X., Qi, L., Hu, X., Xu, R., Yan, M., Shi, Y., et al. (2021). The health effects of wearing facemasks on cardiopulmonary system of healthy young adults: A double-blinded, randomized crossover trial. International Journal of Hygiene and Environmental Health. Citation link
RTube use: EBC was collected at all four visits using a commercially available RTube device following standardized breath-condensate collection procedures.
Study focus: Randomized crossover study using RTube EBC to monitor cardiopulmonary effects of facemask wearing.
56. Caracterização composicional e mineralógica de amostras de condensado do ar exalado por lapidários de Corinto-MG
Research studyAppended client-supplied record
Citation: MS Silva - 2021 - monografias.ufop.br. Caracterização composicional e mineralógica de amostras de condensado do ar exalado por lapidários de Corinto-MG. Citation link
RTube use: (EBCs/Exhaled Breath Condensate) por lapidários de Corinto … internamente um tubo plástico (RTubes®/ Respiratory Research … De acordo com a fabricante dos RTubes®, esse tipo de
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2020
57. Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate
Research study
Citation: Wu, C. M., Adetona, A., Song, C., Naeher, L., et al. (2020). Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate. Journal of Occupational and Environmental Hygiene. Citation link
RTube use: EBC was collected on burn and non-burn days using the RTube breath condensate collection device; RTubes were stored on dry ice immediately after sampling.
Study focus: Wildland firefighter exposure study using RTube EBC to track acute pulmonary responses to smoke.
58. Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate?
Research study
Citation: Sauvain, J. J., Edmé, J. L., Wild, P., Suarez, G., et al. (2020). Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate? Journal of Breath Research. Citation link
RTube use: The authors checked possible RTube contribution to anion concentration by adding Milli-Q water to RTubes and shaking them before assessing participant EBC anion patterns.
Study focus: Occupational/environmental particle-exposure study using RTube EBC and device-blank controls.
59. Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction
Methods / analytical study
Citation: Nishii, K., Ohashi, K., Tamura, T., et al. (2020). Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction. Oncology Letters. Citation link
RTube use: Twenty-one EBC samples were collected using the RTube method and analyzed by droplet digital PCR for EGFR mutations.
Study focus: Lung cancer molecular diagnostics study using RTube EBC for EGFR mutation detection.
60. Measurement of short-chain fatty acids in respiratory samples: keep your assay above the water line
Methods / analytical study
Citation: Yue, M., Kim, J. H., Evans, C. R., Kachman, M., et al. (2020). Measurement of short-chain fatty acids in respiratory samples: Keep your assay above the water line. American Journal of Respiratory and Critical Care Medicine. Citation link
RTube use: EBC was acquired with an RTube breath condensate collection device according to manufacturer instructions and ATS/ERS recommendations for respiratory sample comparison.
Study focus: Analytical respiratory chemistry study using RTube EBC for short-chain fatty acid measurement concerns.
61. A randomized controlled pilot study of CPAP for patients with chronic cough and obstructive sleep apnea
Research study
Citation: Sundar, K. M., Willis, A. M., Smith, S., Hu, N., Kitt, J. P., & Birring, S. S. (2020). A randomized, controlled, pilot study of CPAP for patients with chronic cough and obstructive sleep apnea. Lung. Citation link
RTube use: EBC was obtained with the RTube breath condensate collection system to assess airway inflammation before and after CPAP intervention.
Study focus: Sleep-disordered breathing/chronic cough trial using RTube EBC as an airway inflammation measure.
62. Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: a cross-sectional pilot study
Research study
Citation: Terrington, D. L., Kim, J. W., Ravenhill, G., et al. (2020). Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: A cross-sectional pilot study. Journal of Breath Research. Citation link
RTube use: Paired serum and EBC samples were collected using RTube under clinical guideline recommendations; soluble IL-2 receptor was measured in condensate and serum.
Study focus: Sarcoidosis pilot biomarker study using RTube EBC for local airway immune-marker assessment.
63. Characterization of exhaled breath condensate non-exchangeable hydrogen functional types and lung function of wildland firefighters
Research study
Citation: Nelson, J., Chalbot, M. C. G., Pavicevic, Z., et al. (2020). Characterization of exhaled breath condensate non-exchangeable hydrogen functional types and lung function of wildland firefighters. Journal of Breath Research. Citation link
RTube use: EBC was collected from wildland firefighters using RTube-based breath-condensate methods to profile condensate chemistry after wildfire smoke exposure.
Study focus: Firefighter smoke-exposure study using RTube EBC for metabolic/chemical profiling and lung-function comparison.
64. Airway hydrogen peroxide during a naturalistic period of sustained psychological stress in individuals with asthma and healthy controls
Research study
Citation: Werchan, C. (2020). Airway hydrogen peroxide during a naturalistic period of sustained psychological stress in individuals with asthma and healthy controls. Southern Methodist University thesis. Citation link
RTube use: EBC was collected with an RTube device from Respiratory Research and used to measure airway hydrogen peroxide alongside peak-flow and spirometry values.
Study focus: Asthma/stress biomarker study using RTube EBC for hydrogen peroxide measurement.
65. Critical relevance of stochastic effects on low-bacterial-biomass 16S rRNA gene analysis
Research study
Citation: Erb-Downward, J. R., Falkowski, N. R., D’Souza, J. C., et al. (2020). Critical relevance of stochastic effects on low-bacterial-biomass 16S rRNA gene analysis. mBio. Citation link
RTube use: EBC samples and fresh RTube water controls were obtained using the RTube collection system to test low-biomass microbiome contamination and stochastic signal effects.
Study focus: Microbiome-methodology study using RTube EBC to assess contamination and low-biomass sequence interpretation.
66. Inflammation in children with neuromuscular disorders and sleep disordered breathing
Research study
Citation: Trucco, F., Carruthers, E., Davies, J. C., Simonds, A. K., et al. (2020). Inflammation in children with neuromuscular disorders and sleep disordered breathing. Sleep Medicine. Citation link
RTube use: Children wore a nose clip and breathed tidally for 10 minutes into an RTube to collect EBC for airway inflammatory marker analysis.
Study focus: Pediatric sleep/neuromuscular disease study using RTube EBC to assess airway inflammation.
67. Early diagnosis and screening in lung cancer
Research studyAppended client-supplied record
Citation: C Cainap, LA Pop, O Balacescu… - American Journal of …, 2020 - ncbi.nlm.nih.gov. Early diagnosis and screening in lung cancer. Citation link
RTube use: condensate analysis and specific genomic approaches. … use EcoScreen, TuboDECCS, RTube, ANACON condenser is … also studies that used the Rtube condensers and still manage to
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
68. Clinical Application of Micrornas in Exhaled Breath Condensate and Bronchial Brushings as Early Diagnostic Biomarkers for Lung Cancer
Conference abstractAppended client-supplied record
Citation: BR Pattnaik, S Chakraborty, P Bajpai, J Tak… - B110. IMAGING AND …, 2020 - atsjournals.org. Clinical Application of Micrornas in Exhaled Breath Condensate and Bronchial Brushings as Early Diagnostic Biomarkers for Lung Cancer. Citation link
RTube use: miRNA signatures in the exhaled breath condensate (EBC) were found useful for early … collected from 20 NSCLC patients, using RTubes. miRNA isolation followed by cDNA preparation
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
69. Hyperpnoea-induced bronchoconstriction: Prevalence in athletes, novel measure of airway inflammation, & treatment with the prebiotic Bimuno …
Thesis / dissertationAppended client-supplied record
Citation: R Needham - 2020 - search.proquest.com. Hyperpnoea-induced bronchoconstriction: Prevalence in athletes, novel measure of airway inflammation, & treatment with the prebiotic Bimuno …. Citation link
RTube use: to sample collection and place over the RTubes condensing chamber with the thermal … RTube condensing chamber surface temperature during a 10 minute exhaled breath condensate
Study focus: Thesis / dissertation involving RTube/EBC product use as represented in the linked source excerpt.
70. JR E
Research studyAppended client-supplied record
Citation: … ) fluid, and exhaled breath condensate (EBC) samples and … were obtained using the RTube collection system from … -distilled water over a fresh RTube and collecting the water. Isolation …. JR E. Citation link
RTube use:
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2019
71. Noninvasive glucose detection in exhaled breath condensate
Methods / analytical study
Citation: Tankasala, D., & Linnes, J. C. (2019). Noninvasive glucose detection in exhaled breath condensate. Translational Research. Citation link
RTube use: The study discussed and used EBC collection approaches including RTube-style condensation for glucose measurement in breath condensate.
Study focus: Noninvasive diagnostic technology study evaluating EBC glucose measurement.
72. cfDNA in exhaled breath condensate and contamination by ambient air: toward volatile biopsies
Research study
Citation: Koc, A., Goksel, T., Pelit, L., Korba, K., et al. (2019). cfDNA in exhaled breath condensate (EBC) and contamination by ambient air: Toward volatile biopsies. Journal of Breath Research. Citation link
RTube use: The study examined cell-free DNA in EBC and ambient-air contamination issues using commercial breath-condensate collection systems including the RTube.
Study focus: Liquid-biopsy methodology study addressing cfDNA recovery and contamination in RTube-type EBC.
73. Initial discovery of exhaled small polar energetics-related metabolites by GC-MS for lung cancer risk assessment
Conference abstract
Citation: Spivack, S., Shi, M. K., Patel, D., Desai, A., Dobkin, J., et al. (2019). Initial discovery of exhaled small polar energetics-related metabolites by GC-MS for lung cancer risk assessment. Journal of Thoracic Oncology. Citation link
RTube use: EBC from lung cancer patients and controls was collected noninvasively with a handheld RTube device for GC-MS analysis of small polar metabolites.
Study focus: Lung cancer metabolomics study using RTube EBC for risk-assessment metabolite discovery.
74. Proteome profiling of the exhaled breath condensate after long-term spaceflights
Research study
Citation: Kononikhin, A. S., Brzhozovskiy, A. G., et al. (2019). Proteome profiling of the exhaled breath condensate after long-term spaceflights. International Journal of Molecular Sciences. Citation link
RTube use: Cosmonaut EBC was collected before and after long-duration spaceflight using breath-condensate methods indexed to RTube/ECoScreen work, enabling proteomic comparison of respiratory condensate.
Study focus: Space medicine proteomics study using EBC to monitor physiological changes after long-term spaceflight.
75. The role of microRNAs in chronic Pseudomonas lung infection in cystic fibrosis
Research study
Citation: Fesen, K., Silveyra, P., Fuentes, N., Nicoleau, M., et al. (2019). The role of microRNAs in chronic Pseudomonas lung infection in cystic fibrosis. Respiratory Medicine. Citation link
RTube use: EBC was collected from 27 subjects; condensate was recovered from the RTube with a syringe-style plunger and analyzed for microRNAs.
Study focus: Cystic fibrosis study using RTube EBC microRNA analysis in chronic Pseudomonas infection.
76. Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries
Research study
Citation: Singh, K. P., Lawyer, G., Muthumalage, T., et al. (2019). Systemic biomarkers in electronic cigarette users: Implications for noninvasive assessment of vaping-associated pulmonary injuries. ERJ Open Research. Citation link
RTube use: EBC samples were collected during tidal breathing for 10 minutes using an RTube collection device and analyzed for vaping-related biomarker changes.
Study focus: E-cigarette exposure study using RTube EBC to assess noninvasive biomarkers of pulmonary injury.
77. Low-flow domiciliary oxygen as a mechanism of ongoing oxidative stress
Research study
Citation: Stulce, J. M., Biddle, C., & Vacchiano, C. (2019). Low-flow domiciliary oxygen as a mechanism of ongoing oxidative stress. Respiratory Care. Citation link
RTube use: EBC was collected from each participant using an RTube device and analyzed for isofuran/oxidative-stress indicators in the context of domiciliary oxygen exposure.
Study focus: COPD/oxygen-therapy study using RTube EBC to measure oxidative stress.
2018
78. Brief report on the detection of the EGFR T790M mutation in exhaled breath condensate from lung cancer patients
Methods / analytical study
Citation: Smyth, R. J., Toomey, S. M., Sartori, A., O’Hanrahan, E., et al. (2018). Brief report on the detection of the EGFR T790M mutation in exhaled breath condensate from lung cancer patients. Journal of Thoracic Oncology. Citation link
RTube use: EBC was collected with an RTube breath condensate device with the cooling sleeve at −70 °C; patients breathed into the RTube for downstream EGFR T790M mutation detection.
Study focus: Lung cancer molecular diagnostics study using RTube EBC for resistance-mutation detection.
79. MicroRNAs in exhaled breath condensate and bronchial brushings as biomarkers for early diagnosis of lung cancer
Conference abstract
Citation: Pattnaik, B., Chakraborty, S., Bajpai, P., Agrawal, A., et al. (2018). MicroRNAs in exhaled breath condensate and bronchial brushings as biomarkers for early diagnosis of lung cancer. Journal of Thoracic Oncology. Citation link
RTube use: Samples were collected from suspected NSCLC patients during outpatient visits using RTube, followed by microRNA isolation and analysis.
Study focus: Early lung cancer biomarker study using RTube EBC microRNAs.
80. Proteomic characterization of human exhaled breath condensate
Research study
Citation: Lacombe, M., Marie-Desvergne, C., et al. (2018). Proteomic characterization of human exhaled breath condensate. Journal of Breath Research. Citation link
RTube use: EBC was obtained noninvasively by condensation of exhaled air using RTube-indexed breath-condensate collection procedures for in-depth proteomic characterization.
Study focus: Human EBC proteomics method study defining protein profiles in RTube-type condensate.
81. Exhaled breath condensate nitrite in premature infants with bronchopulmonary dysplasia
Research study
Citation: Yen, E. Y., Weinberger, B. I., Laumbach, R. J., et al. (2018). Exhaled breath condensate nitrite in premature infants with bronchopulmonary dysplasia. Journal of Neonatal-Perinatal Medicine. Citation link
RTube use: The RTube was encased at −80 °C, connected into the ventilator circuit, then capped and maintained on dry ice after collection for nitrite measurement.
Study focus: Neonatal BPD study using ventilator-adapted RTube EBC to measure nitrite.
82. Effect of temperature control on the metabolite content in exhaled breath condensate
Research study
Citation: Zamuruyev, K. O., Borras, E., Pettit, D. R., Aksenov, A. A., et al. (2018). Effect of temperature control on the metabolite content in exhaled breath condensate. Analytica Chimica Acta. Citation link
RTube use: A regular passively cooled RTube and a custom thermoelectric RTube setup were compared to determine how condensation temperature changes metabolite content in EBC.
Study focus: EBC method study using RTube to test temperature effects on metabolite recovery.
83. Determination of thiocyanate in exhaled breath condensate
Research study
Citation: Chandler, J. D., Horati, H., Walker, D. I., Pagliano, E., et al. (2018). Determination of thiocyanate in exhaled breath condensate. Free Radical Biology and Medicine. Citation link
RTube use: Donors breathed steadily for 10 minutes into an RTube with an insulated aluminum sleeve precooled to −80 °C; EBC thiocyanate was measured analytically.
Study focus: Analytical biomarker study using RTube EBC for thiocyanate detection.
84. Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients
Methods / analytical study
Citation: Bhimji, A., Bhaskaran, A., Singer, L. G., Kumar, D., et al. (2018). Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients. Clinical Microbiology and Infection. Citation link
RTube use: Standardized EBC collection used a refrigerated RTube condenser; neat and diluted EBC galactomannan results were compared with BAL fluid.
Study focus: Invasive aspergillosis diagnostic study using RTube EBC as a noninvasive comparator to BAL.
85. Evaluation of a new method for the collection and measurement of 8-isoprostane in exhaled breath for nanoparticle exposure biomonitoring
Methods / analytical study
Citation: Marie-Desvergne, C., Dubosson, M., et al. (2018). Evaluation of a new method for the collection and measurement of 8-isoprostane in exhaled breath for future application in nanoparticle exposure biomonitoring. Journal of Breath Research. Citation link
RTube use: The new method was evaluated and compared with RTube collection for exhaled breath condensate 8-isoprostane biomonitoring.
Study focus: Occupational biomonitoring methods study comparing RTube EBC with alternate collection for oxidative stress measurement.
86. Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics
Research study
Citation: Kilk, K., Aug, A., Ottas, A., Soomets, U., Altraja, S., et al. (2018). Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics. International Journal of Molecular Sciences. Citation link
RTube use: EBC was collected using single-use RTube sets and integrated with blood metabolomics and clinical characteristics for COPD phenotyping.
Study focus: COPD metabolomics study using RTube EBC for molecular phenotyping.
87. Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls
Research study
Citation: Kurti, S. P., Emerson, S. R., Smith, J. R., et al. (2018). Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls. Applied Physiology, Nutrition, and Metabolism. Citation link
RTube use: Participants breathed into an RTube, yielding about 1.0–1.5 mL of EBC; samples were plunged from RTubes, aliquoted, and analyzed for 8-isoprostane responses.
Study focus: Exercise physiology study using RTube EBC to measure airway oxidative stress.
88. Soluble HLA-I and HLA-II molecules are potential prognostic markers of progression of systemic and local inflammation in COPD
Research study
Citation: Kubysheva, N., Soodaeva, S., Novikov, V., Eliseeva, T., et al. (2018). Soluble HLA-I and HLA-II molecules are potential prognostic markers of progression of systemic and local inflammation in patients with COPD. Disease Markers. Citation link
RTube use: EBC was collected within 20 minutes after mouth rinsing using the RTube system; serum and condensate were stored for soluble HLA measurements.
Study focus: COPD inflammatory-progression study using RTube EBC to quantify soluble immune markers.
89. Clinical significance of leptin in exhaled breath condensate before and after OSAHS surgery
Research study
Citation: Liang, W., Wu, P., Zhu, H., Deng, Y., Guan, Y., et al. (2018). Clinical significance of leptin in exhaled breath condensate before and after OSAHS surgery. New Medicine. Citation link
RTube use: EBC was collected with an RTube EBC collector from Respiratory Research according to breath-condensate recommendations, then leptin was measured around OSAHS surgery.
Study focus: Sleep apnea surgery study using RTube EBC leptin as a disease/severity biomarker.
90. Exhaled breath condensate: an update
Conference abstractAppended client-supplied record
Citation: MD Davis, AJ Montpetit - Immunology and Allergy …, 2018 - immunology.theclinics.com. Exhaled breath condensate: an update. Citation link
RTube use: RTube Respiratory Research, USA More total EBC collections performed using RTube than other systems. Multiple collections can be performed concurrently. More common in North
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
91. Metabolomics as a Novel Diagnostic Approach for Asthma
Research studyAppended client-supplied record
Citation: B Fatemeh Nobakht, A Arefi Oskouie - Genomic Approach to Asthma, 2018 - Springer. Metabolomics as a Novel Diagnostic Approach for Asthma. Citation link
RTube use: NMR-based metabolomics analysis of EBC showed condense … plastic RTubes and plastic RTubes vs. TURBO-DECCS … to the glass RTube compared to plastic RTubes (approximately
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
92. P1. 11-12 Interrogation of an Exhaled MicroRNA Panel for Lung Cancer Risk Assessment
Conference abstractAppended client-supplied record
Citation: S Spivack - Journal of Thoracic Oncology, 2018 - jto.org. P1. 11-12 Interrogation of an Exhaled MicroRNA Panel for Lung Cancer Risk Assessment. Citation link
RTube use: Exhaled breath condensate (EBC) contains airway lining fluid molecules, including nucleic … EBC was collected non-invasively, using a handheld commercial RTube® device in a clinical
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
93. Abstracts from the 11th International Symposium on Minimal Residual Disease, 3–5 May 2018, Montpellier, France
Research studyAppended client-supplied record
Citation: C Alix-Panabières, K Pantel - Clinical & Experimental Metastasis, 2018 - Springer. Abstracts from the 11th International Symposium on Minimal Residual Disease, 3–5 May 2018, Montpellier, France. Citation link
RTube use: sought to investigate the ability of exhaled breath condensate (EBC) to detect EGFR-T790M … using the RTube with the cooling sleeve at − 70 C. Patients breathed into the RTube for 10
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
94. P1. 11-10 Optimizing Radiomics Features by Minimizing Boundary Effects and Normalizing with Opposite Lung Tissue Characteristics
Conference abstractAppended client-supplied record
Citation: S Seyyedi, J Mayo, S Atkar-Khattra, R Yuan… - Journal of Thoracic …, 2018 - jto.org. P1. 11-10 Optimizing Radiomics Features by Minimizing Boundary Effects and Normalizing with Opposite Lung Tissue Characteristics. Citation link
RTube use: Exhaled breath condensate (EBC) contains airway lining fluid molecules, including nucleic … Method: EBC was collected non-invasively, using a handheld commercial RTube® device in
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
2017
95. Exhaled breath condensate metabolome clusters for endotype discovery in asthma
Research study
Citation: Sinha, A., Desiraju, K., Aggarwal, K., Kutum, R., et al. (2017). Exhaled breath condensate metabolome clusters for endotype discovery in asthma. Journal of Translational Medicine. Citation link
RTube use: EBC was collected using RTubes from Respiratory Research, designed to collect condensate without contamination; samples were immediately stored at −80 °C for metabolomics.
Study focus: Asthma endotyping study using RTube EBC metabolomic clustering.
96. Correlation between TNF-α and IL-1β in exhaled breath condensate and pulmonary function
Research study
Citation: Lin, X., Fan, Y., Wang, X., Chi, M., Li, X., Zhang, X., et al. (2017). Correlation between tumor necrosis factor-α and interleukin-1β in exhaled breath condensate and pulmonary function. American Journal of the Medical Sciences. Citation link
RTube use: EBC was collected with an RTube condensate collector; approximately 2 mL was collected and immediately stored at −80 °C for TNF-α and IL-1β analysis.
Study focus: Respiratory inflammation study using RTube EBC cytokines and lung-function correlations.
97. Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children
Research study
Citation: Kwak, B. O., & Park, Y. M. (2017). Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children. Allergy, Asthma & Respiratory Disease. Citation link
RTube use: EBC samples were collected with RTube at baseline and follow-up points, and leukotriene E4 was used to assess inflammation and treatment effect.
Study focus: Pediatric allergic rhinitis study using RTube EBC leukotriene E4 as a noninvasive biomarker.
99. The novel detection of EGFR-T790M mutations in exhaled breath condensate
Methods / analytical study
Citation: Smyth, R., Toomey, S., Sartori, A., O’Hanrahan, E., Cuffe, S., et al. (2017). The novel detection of EGFR-T790M mutations in exhaled breath condensate. Journal of Clinical Oncology/ASCO Abstracts. Citation link
RTube use: EBC samples were collected using the RTube device and compared with plasma for EGFR-T790M mutation detection.
Study focus: Lung cancer resistance-mutation study using RTube EBC as a noninvasive molecular sample.
100. Aspergillus galactomannan detection in exhaled breath condensate for the diagnosis of invasive aspergillosis in lung transplant recipients
Conference abstract
Citation: Bhimji, A., Bhaskaran, A., Singer, L. G., Kumar, D., et al. (2017). Aspergillus galactomannan detection in exhaled breath condensate for the diagnosis of invasive aspergillosis in lung transplant recipients. Journal of Heart and Lung Transplantation. Citation link
RTube use: Standardized EBC was collected using a refrigerated RTube condenser, with BAL performed immediately afterward; EBC galactomannan was analyzed neat and diluted.
Study focus: Transplant infectious-disease study using RTube EBC for Aspergillus diagnostic testing.
101. Validation of nanoparticle tracking analysis to measure pulmonary nanoparticle content: size distribution in exhaled breath condensate depends on occupational exposure
Methods / analytical study
Citation: Sauvain, J. J., Suarez, G., Edmé, J. L., et al. (2017). Validation of nanoparticle tracking analysis to measure pulmonary nanoparticle content: The size distribution in exhaled breath condensate depends on occupational exposure. Journal of Breath Research. Citation link
RTube use: The study verified RTubes and microtubes for particle contamination by adding filtered water and shaking before analyzing EBC nanoparticle distributions.
Study focus: Occupational exposure method study using RTube EBC for nanoparticle tracking analysis.
102. Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD
Research study
Citation: Lin, X., Wu, Z., Fan, Y., Chi, M., et al. (2017). Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD. Molecular Medicine Reports. Citation link
RTube use: EBC was collected with an RTube condenser for 10–15 minutes, yielding 1–3 mL; condensate was removed to cryovials and stored at −80 °C before surfactant-protein analysis.
Study focus: Lung cancer/COPD study using RTube EBC surfactant proteins and lung-function correlations.
103. Exhaled breath condensate acidification occurs during surgery for abdominal cancer
Research study
Citation: Mahairidou, A., Rodopoulou, S., Tomos, I., et al. (2017). Exhaled breath condensate acidification occurs during surgery for abdominal cancer. Anticancer Research. Citation link
RTube use: About 1.0–1.5 mL EBC was collected; during mechanical ventilation, the RTube was inserted early into the expiratory limb to obtain adequate condensate volume.
Study focus: Perioperative oncology study using RTube EBC pH/acidification as an intraoperative lung-injury marker.
104. EGEA collection: a biobank devoted to asthma and asthma-related phenotypes
Research study
Citation: Nadif, R., Bouzigon, E., et al. (2017). EGEA collection: A biobank devoted to asthma and asthma-related phenotypes. Open Journal of Bioresources. Citation link
RTube use: EBC was collected with an RTube under standardized procedures as part of the EGEA asthma-related phenotype biobank, alongside FeNO and other phenotyping measures.
Study focus: Asthma biobank study using standardized RTube EBC collection for future biomarker research.
105. The association of e-cigarette use with exposure to nickel and chromium: a preliminary study of non-invasive biomarkers
Research study
Citation: Aherrera, A., Olmedo, P., Grau-Perez, M., Tanda, S., et al. (2017). The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers. Environmental Research. Citation link
RTube use: Urine, saliva, and EBC were collected; EBC used an RTube system for 10 minutes to assess nickel and chromium exposure in e-cigarette users.
Study focus: E-cigarette metal-exposure study using RTube EBC as a noninvasive biomonitoring matrix.
106. Mycoplasma pneumoniae and health outcomes in children with asthma
Research study
Citation: Wood, P. R., Kampschmidt, J. C., Dube, P. H., et al. (2017). Mycoplasma pneumoniae and health outcomes in children with asthma. Annals of Allergy, Asthma & Immunology. Citation link
RTube use: EBC was collected using the RTube and measured for pH with a micro pH electrode as part of asthma outcome assessment.
Study focus: Pediatric asthma infection/outcomes study using RTube EBC pH.
107. Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study
Research study
Citation: Andrianjafimasy, M., Zerimech, F., Akiki, Z., et al. (2017). Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study. European Respiratory Journal. Citation link
RTube use: EBC was collected using RTube according to a standardized method; the RTube was rinsed with deionized water and dried before participant collection.
Study focus: Asthma epidemiology study using RTube EBC oxidative-stress biomarkers.
108. Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates
Research study
Citation: Dierschke, K., Isaxon, C., Andersson, U. B. K., et al. (2017). Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates. International Archives of Occupational and Environmental Health. Citation link
RTube use: Participants breathed into an RTube cooled to −25 °C; condensate was allocated for leukotriene B4 and other inflammatory marker assays after welding-fume exposure.
Study focus: Controlled occupational exposure study using RTube EBC to assess nanoparticle-induced airway inflammation.
109. Effects of dietary nitrate on respiratory physiology at high altitude: Results from the Xtreme Alps study
Research study
Citation: Cumpstey, A. F., Hennis, P. J., Gilbert-Kawai, E. T., et al. (2017). Effects of dietary nitrate on respiratory physiology at high altitude: Results from the Xtreme Alps study. Nitric Oxide. Citation link
RTube use: EBC nitrite measurements were collected as part of the high-altitude nitrate intervention protocol; the RTube corpus identifies breath-condensate collection in this study.
Study focus: High-altitude physiology study using EBC nitrite to assess respiratory effects of dietary nitrate.
110. Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males
Research study
Citation: Kurti, S. P., Emerson, S. R., Rosenkranz, S. K., Teeman, C. S., et al. (2017). Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males. Nutrition Research. Citation link
RTube use: After 10 minutes of collection, roughly 1.5 mL EBC was obtained and immediately frozen at −60 °C in RTubes; exhaled 8-isoprostane was analyzed in triplicate.
Study focus: Nutrition/oxidative-stress study using RTube EBC to measure meal-linked airway oxidative changes.
111. Serum sST2 levels predict severe exacerbation of asthma: a potential implication for neutrophilic asthma
Conference abstract
Citation: Watanabe, M., Nakamoto, K., Sada, M., Inui, T., et al. (2017). Serum sST2 levels predict severe exacerbation of asthma: A potential implication for neutrophilic asthma. American Thoracic Society Abstracts. Citation link
RTube use: Airway oxidative stress was assessed by obtaining EBC using an RTube and measuring hydrogen peroxide levels.
Study focus: Asthma exacerbation biomarker study pairing serum sST2 with RTube EBC hydrogen peroxide.
112. Clinical risk factors for invasive aspergillosis in lung transplant recipients: results of an international cohort study
Conference abstractAppended client-supplied record
Citation: C Aguilar, B Hamandi, C Fegbeutel… - The Journal of Heart …, 2017 - jhltonline.org. Clinical risk factors for invasive aspergillosis in lung transplant recipients: results of an international cohort study. Citation link
RTube use: The ability to detect GM in exhaled breath condensate (EBC) would be significantly less … Standardized EBC collection was performed using a refrigerated condenser (RTube), and BAL
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
113. 소아 알레르기비염에서 호기호흡농축물 내의 류코트리엔 E4 를 이용한 치료 효과와 염증 평가
Research studyAppended client-supplied record
Citation: 곽병옥， 박용민 - Allergy, Asthma & Respiratory Disease, 2017 - aard.or.kr. 소아 알레르기비염에서 호기호흡농축물 내의 류코트리엔 E4 를 이용한 치료 효과와 염증 평가. Citation link
RTube use: Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (… EBC samples were collected with RTube. Each parameter was checked at 0, 2, and 10
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
114. Значение растворимых молекул клеточной адгезии, метаболитов оксида азота, эндотелина-1 и их ассоциаций как маркеров прогрессирования воспаления …
Research studyAppended client-supplied record
Citation: НИ Кубышева, ЛБ Постникова… - Современные …, 2017 - cyberleninka.ru. Значение растворимых молекул клеточной адгезии, метаболитов оксида азота, эндотелина-1 и их ассоциаций как маркеров прогрессирования воспаления …. Citation link
RTube use: blood serum and exhaled breath condensate. Results. The … blood and in exhaled breath condensate. For the patients with … полости с помощью системы RTube (Respiratory Research
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2016
115. Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler
Research study
Citation: Zamuruyev, K. O., Aksenov, A. A., et al. (2016). Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler. Journal of Breath Research. Citation link
RTube use: The standard RTube was used as the comparator benchmark; the paper describes RTube condensation starting near −54 °C and warming toward 0 °C during a 10-minute collection, affecting volume and reproducibility.
Study focus: Breath-metabolomics methodology study benchmarking an optimized sampler against RTube.
116. Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate
Methods / analytical study
Citation: Mehta, A., Cordero, J., Dobersch, S., et al. (2016). Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate. EMBO Molecular Medicine. Citation link
RTube use: EBC collection was performed using the RTube and published EBC guidelines; condensate RNA/transcript isoforms were analyzed for lung-cancer diagnosis.
Study focus: Molecular lung cancer diagnostic study using RTube EBC for transcript isoform detection.
117. Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate
Research study
Citation: Marie-Desvergne, C., Dubosson, M., Touri, L., et al. (2016). Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate. Journal of Breath Research. Citation link
RTube use: One RTube out of every 50 was reserved as a blank; blank RTubes were compared with participant EBC to quantify background particles and metal contamination.
Study focus: Occupational airport-exposure study using RTube EBC with device blanks for nanoparticle/metal biomonitoring.
118. A method for the preservation and determination of welding fume nanoparticles in exhaled breath condensate
Methods / analytical study
Citation: Gschwind, S., Graczyk, H., Günther, D., et al. (2016). A method for the preservation and determination of welding fume nanoparticles in exhaled breath condensate. Environmental Science: Processes & Impacts. Citation link
RTube use: EBC was used as the preserved nanoparticle matrix for occupational exposure analysis; the study appears in the RTube EBC corpus and developed preservation/quantification methods for welding-fume nanoparticles.
Study focus: Occupational nanoparticle exposure methodology using EBC collected in RTube-linked workflows.
119. The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts
Research study
Citation: Fedorchenko, K. Y., Ryabokon, A. M., Kononikhin, A. S., et al. (2016). The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts. Russian Chemical Bulletin. Citation link
RTube use: Cosmonaut EBC was collected before and after space flight for protein-composition analysis, with the RTube index identifying the work within the RTube breath-condensate corpus.
Study focus: Space-medicine proteomics study using EBC to monitor respiratory protein shifts after spaceflight.
120. Methodological issues and possible clinical implications for exhaled breath condensate pH in asthma
Methods / analytical studyAppended client-supplied record
Citation: A Bikov, I Horvath - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com. Methodological issues and possible clinical implications for exhaled breath condensate pH in asthma. Citation link
RTube use: (Jaeger) and the polypropylene Rtube (Respiratory Research) devices. Higher pH values were reported when EBC was collected with the EcoScreen than the Rtube device for neat [37,
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
121. 1H NMR To Explore the Metabolome of Exhaled Breath Condensate in α1-Antitrypsin Deficient Patients: A Pilot Study
Research studyAppended client-supplied record
Citation: C Airoldi, C Ciaramelli, M Fumagalli… - Journal of Proteome …, 2016 - ACS Publications. 1H NMR To Explore the Metabolome of Exhaled Breath Condensate in α1-Antitrypsin Deficient Patients: A Pilot Study. Citation link
RTube use: Exhaled breath condensate was collected using an RTube condensing kit (Respiratory … exhaled breath to condense along the walls of the tube. The volume of condensate collected was
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
122. Enhancing asthma self‐management in rural school‐aged children: A randomized controlled trial
Research studyAppended client-supplied record
Citation: SD Horner, A Brown, SA Brown… - The Journal of Rural …, 2016 - Wiley Online Library. Enhancing asthma self‐management in rural school‐aged children: A randomized controlled trial. Citation link
RTube use: The child was directed to breathe normally into the RTube mouthpiece for 6 minutes and this yielded sufficient volume of condensate. The RTube was capped and placed in a cold chest
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
123. Cardiovascular and pulmonary health effects of air pollution-long term effects in Sweden and effects of wood smoke
Research studyAppended client-supplied record
Citation: L Stockfelt - 2016 - gupea.ub.gu.se. Cardiovascular and pulmonary health effects of air pollution-long term effects in Sweden and effects of wood smoke. Citation link
RTube use: A main reason for this was probably the method of collecting breath condensate, the RTube, chosen for being transportable and practical in this study with a high number of participants
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
124. Systemic inflammation and oxidative stress post‐lung resection: Effect of pretreatment with N‐acetylcysteine
Research studyAppended client-supplied record
Citation: AJ Bastin, N Davies, E Lim, GJ Quinlan… - …, 2016 - Wiley Online Library. Systemic inflammation and oxidative stress post‐lung resection: Effect of pretreatment with N‐acetylcysteine. Citation link
RTube use: blood cell glutathione and exhaled breath condensate pH were measured pre- and … condensate (EBC; 0.5 to 1 mL) was collected in a polypropylene tube with a one-way valve (Rtube,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2015
125. Exhaled breath condensate: technical and diagnostic aspects
Research studyAppended client-supplied record
Citation: EM Konstantinidi, AS Lappas, AS Tzortzi… - The Scientific World …, 2015 - hindawi.com. Exhaled breath condensate: technical and diagnostic aspects. Citation link
RTube use: the 30-year progress of research on exhaled breath condensate in a disease-based approach. … using Rtube, where the temperature of cooling chamber is increasing with condensation,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
126. Electrospun polystyrene/graphene nanofiber film as a novel adsorbent of thin film microextraction for extraction of aldehydes in human exhaled breath condensates
Research studyAppended client-supplied record
Citation: J Huang, H Deng, D Song, H Xu - Analytica chimica acta, 2015 - Elsevier. Electrospun polystyrene/graphene nanofiber film as a novel adsorbent of thin film microextraction for extraction of aldehydes in human exhaled breath condensates. Citation link
RTube use: Exhaled breath condensate (EBC) samples were collected by a commercially available condenser (RTube™, Respiratory Research, Inc., USA). Morphology of the synthesized
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
127. Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis
Research studyAppended client-supplied record
Citation: AL Lee, BM Button, L Denehy, S Roberts… - Respiratory …, 2015 - rc.rcjournal.com. Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis. Citation link
RTube use: During the 24-h study period, EBC was collected using RTubes, with the RTube sleeve … consistent with the method of collection using the RTube. EBC pH was measured before freezing
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
128. The use of exhaled breath condensate to assess surfactant dysfunction from chlorine gas exposure
Thesis / dissertationAppended client-supplied record
Citation: CA Edwards - 2015 - search.proquest.com. The use of exhaled breath condensate to assess surfactant dysfunction from chlorine gas exposure. Citation link
RTube use: , acting as a syringe to pool the condensate near the top of the RTube for easysample collection. At this time, there is a sample volume of 0.5-1.5mL ready for surfacetension analysis.
Study focus: Thesis / dissertation involving RTube/EBC product use as represented in the linked source excerpt.
129. Analysis of aldehydes in human exhaled breath condensates by in-tube SPME-HPLC
Research studyAppended client-supplied record
Citation: SL Wang, S Hu, H Xu - Analytica Chimica Acta, 2015 - Elsevier. Analysis of aldehydes in human exhaled breath condensates by in-tube SPME-HPLC. Citation link
RTube use: available handheld EBC collection system, RTube™ technique. Eight lung cancer patients … collection tube inserted in the cooled aluminum sleeve RTube, typically yielding 0.5–2.0 mL
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
130. Conductivity in exhaled breath condensate from subjects with emphysema and type ZZ alpha-1-antitrypsin deficiency
Research studyAppended client-supplied record
Citation: J Stolk, M Fumagalli, S Viglio… - COPD: Journal of Chronic …, 2015 - Taylor & Francis. Conductivity in exhaled breath condensate from subjects with emphysema and type ZZ alpha-1-antitrypsin deficiency. Citation link
RTube use: condensate was collected using an RTube kit (… condense along the walls of the tube. Subjects were asked to breath in this device while wearing a nose clip. The volume of condensate
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
131. Exhaled breath condensate pH decreases following oral glucose tolerance test
Research studyAppended client-supplied record
Citation: A Bikov, J Pako, D Montvai, D Kovacs… - Journal of breath …, 2015 - iopscience.iop.org. Exhaled breath condensate pH decreases following oral glucose tolerance test. Citation link
RTube use: Exhaled breath condensate was collected for 10 min using a commercial device (Rtube, … After collection, condensate fluid was aliquoted into 1.5 ml polypropylene Eppendorf
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
132. Adipokines and cysteinyl leukotrienes in the pathogenesis of asthma
Research studyAppended client-supplied record
Citation: MJ Coffey, B Torretti, P Mancuso - Journal of allergy, 2015 - hindawi.com. Adipokines and cysteinyl leukotrienes in the pathogenesis of asthma. Citation link
RTube use: Exhaled breath condensate (EBC) was collected with RTube to determine airway lining fluid … median log LTB4 levels in exhaled breath condensate for nonobese asthmatics as 50 pg/mL
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
133. EBCpH variability in healthy children
Conference abstractAppended client-supplied record
Citation: A Karakatsani, S Rodopoulou, E Samoli… - 2015 - Eur Respiratory Soc. EBCpH variability in healthy children. Citation link
RTube use: Exhaled breath condensate was collected in a standardized manner, using the RTube system from 51 children, 10 years old, participating in the RESPOZE study that investigates the
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
134. Health surveillance study of workers who manufacture multi-walled carbon nanotubes
Research studyAppended client-supplied record
Citation: JS Lee, YC Choi, JH Shin, JH Lee, Y Lee, SY Park… - …, 2015 - Taylor & Francis. Health surveillance study of workers who manufacture multi-walled carbon nanotubes. Citation link
RTube use: The exhaled breath condensate was then collected during 10 min of oral tidal breathing using an RTube™ collection kit (Respiratory Research Inc., Austin, TX), while wearing a nose
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
135. Gratis Journal of Cancer Biology and Therapeutics
Research studyAppended client-supplied record
Citation: A Alnashwan, A Hakamy, B Gongol, A Alismail, M Horn… - 2015 - researchgate.net. Gratis Journal of Cancer Biology and Therapeutics. Citation link
RTube use: In this study, we measured exhaled breath condensate (EBC) levels of biomarkers … Exhaled breath condensates were collected using the RTube™ (Respiratory Research, Inc.,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
136. Plasma VEGF levels and their relation to right ventricular function in pulmonary hypertension
Research studyAppended client-supplied record
Citation: J Pako, A Bikov, K Karlocai, G Csosza… - Clinical and …, 2015 - Taylor & Francis. Plasma VEGF levels and their relation to right ventricular function in pulmonary hypertension. Citation link
RTube use: Exhaled breath condensate was collected with a commercially available device (RTube, … We found that breath condensate VEGF measurements are not suitable to analyse the
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
137. Metal–Organic Framework 199 Film as a Novel Adsorbent of Thin-Film Extraction
Research studyAppended client-supplied record
Citation: S Wang, X Wang, Y Ren, H Xu - Chromatographia, 2015 - Springer. Metal–Organic Framework 199 Film as a Novel Adsorbent of Thin-Film Extraction. Citation link
RTube use: determination of aldehyde in human exhaled breath condensates of lung cancer patients and healthy … EBC samples were collected with a commercially available condenser (RTube™,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
138. Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice
Research studyAppended client-supplied record
Citation: C Oyeniran, JL Sturgill, NC Hait, WC Huang… - Journal of Allergy and …, 2015 - Elsevier. Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. Citation link
RTube use: breath condensates. … an RTube and cooling sleeve (Respiratory Research, Austin, Tex) and from patients admitted to the intensive care unit with a history of asthma by using an RTube
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
139. Effects of cigarette smoke on methacholine-and AMP-induced air trapping in asthmatics
Research studyAppended client-supplied record
Citation: L Prieto, J Palop, R Llusar, S Herrera… - Journal of …, 2015 - Taylor & Francis. Effects of cigarette smoke on methacholine-and AMP-induced air trapping in asthmatics. Citation link
RTube use: ) nitric oxide (NO) and exhaled breath condensate pH were measured in 68 adults (23 current … [Citation13] were obtained using a frozen sampling syringe, whereas we used the RTube.
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2014
140. Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis
Research studyAppended client-supplied record
Citation: SB Montesi, SK Mathai, LN Brenner… - BMC pulmonary …, 2014 - Springer. Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis. Citation link
RTube use: EBC was collected using the handheld RTube™ exhaled breath condensate collector (Respiratory Research, Inc.), according to the manufacturer’s instructions, and following the ATS/
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
141. D31 NONINVASIVE ASSESSMENT OF LUNG DISEASE: The Relationship Of Arginine And Its Metaboites In Exhaled Breath Condensate To Lung Function
Thesis / dissertationAppended client-supplied record
Citation: L Ayyar, J Hsu, F Jahoor, C Kao - American Journal of …, 2014 - search.proquest.com. D31 NONINVASIVE ASSESSMENT OF LUNG DISEASE: The Relationship Of Arginine And Its Metaboites In Exhaled Breath Condensate To Lung Function. Citation link
RTube use: Collection of exhaled breath condensate (EBC) is a non-invasive method of accessing the … breath condensate (EBC) was collected per ATS/ERS recommendations using the Rtube ®
Study focus: Thesis / dissertation involving RTube/EBC product use as represented in the linked source excerpt.
142. Study on the influence factors of exhaled breath condensate pH detection of asthma children
Methods / analytical studyAppended client-supplied record
Citation: C Xu, N Li, X Lin, Y Chen, C Liu, Y Li… - Wei Sheng yan jiu …, 2014 - europepmc.org. Study on the influence factors of exhaled breath condensate pH detection of asthma children. Citation link
RTube use: To explore influence factors of exhaled breath condensate (EBC) pH detection and establish … EBC samples were collected using Rtube EBC collection system, and pH values were
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
143. Exhaled breath condensate as a matrix for combustion-based nanoparticle exposure and health effect evaluation
Research studyAppended client-supplied record
Citation: JJ Sauvain, MSS Hohl, P Wild, JA Pralong… - Journal of aerosol …, 2014 - liebertpub.com. Exhaled breath condensate as a matrix for combustion-based nanoparticle exposure and health effect evaluation. Citation link
RTube use: Before use, the RTube was thoroughly rinsed with ultrapure water and air-dried in a clean … Up to 2 mL of condensate was collected. About 500 μL was used immediately to determine the
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
144. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs
Conference abstractAppended client-supplied record
Citation: A Fernandez-Bustamante, J Klawitter, JE Repine… - …, 2014 - pubs.asahq.org. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Citation link
RTube use: condensate samples were collected with an Rtube™ breath … This Rtube™ consists of a sterile polypropylene collection … ) during the collection period to condense the breath at the inner
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
145. Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial
Research studyAppended client-supplied record
Citation: M Shyamsundar, DF McAuley, MO Shields… - 2014 - journals.lww.com. Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. Citation link
RTube use: and intraoperative exhaled breath condensate pH; alveolar type 1 … Exhaled breath condensate was collected by using RTube (… Exhaled breath condensate was collected from intubated
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
146. Associations between indicators of nitrosative stress and levels of soluble HLA-I, CD95 molecules in patients with COPD
Research studyAppended client-supplied record
Citation: N Kubysheva, S Soodaeva, L Postnikova… - COPD: Journal of …, 2014 - Taylor & Francis. Associations between indicators of nitrosative stress and levels of soluble HLA-I, CD95 molecules in patients with COPD. Citation link
RTube use: ) in the serum of blood and exhaled breath condensate (EBC) in patients with exacerbation of … The exhaled breath condensate was collected using an RTube (USA) system, within 20
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
147. Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city
Research studyAppended client-supplied record
Citation: B Linares Segovia, G Cortés Sandoval… - BMC Pulmonary …, 2014 - Springer. Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. Citation link
RTube use: condensate analysis Exhaled breath condensate collection was performed using the RTube™ … The condensate samples were obtained at an average ambient temperature of 13C. The
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
148. A mutated vitamin D receptor in hereditary vitamin D-resistant rickets prevents induction of bronchial hyperreactivity and inflammation
Conference abstractAppended client-supplied record
Citation: R Bar-Yoseph, L Bentur, A Goldbart… - The Journal of …, 2014 - academic.oup.com. A mutated vitamin D receptor in hereditary vitamin D-resistant rickets prevents induction of bronchial hyperreactivity and inflammation. Citation link
RTube use: The HVDRR patients had different cytokine levels in their exhaled breath condensate (… Exhaled breath condensate EBC samples were collected in RTubes (Respiratory Research, Inc)
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
149. Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study
Research studyAppended client-supplied record
Citation: R Nadif, M Rava, B Decoster… - European …, 2014 - Eur Respiratory Soc. Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study. Citation link
RTube use: The interest in measuring biological markers in exhaled breath condensate (EBC) in … Briefly, the RTube was rinsed with deionised water and dried thoroughly. Participants
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
150. Laboratory and clinical acute effects of active and passive indoor group water-pipe (narghile) smoking
Research studyAppended client-supplied record
Citation: L Bentur, E Hellou, A Goldbart, G Pillar, E Monovich… - Chest, 2014 - Elsevier. Laboratory and clinical acute effects of active and passive indoor group water-pipe (narghile) smoking. Citation link
RTube use: EBC samples were collected in RTubes (Respiratory Research) as previously described.6, 13, … and discussion of exhaled breath condensate parameters and revision of the manuscript.
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
151. Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
Research studyAppended client-supplied record
Citation: S De Prins, F Marcucci, L Sensi, E Van de Mieroop… - Biomarkers, 2014 - Taylor & Francis. Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children. Citation link
RTube use: Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH… using an RTube™ sampling device (Respiratory Research, Inc., Austin, TX). The RTube™
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
152. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters
Research studyAppended client-supplied record
Citation: JA Sarnat, R Golan, R Greenwald, AU Raysoni… - Environmental …, 2014 - Elsevier. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Citation link
RTube use: EBC was collected during a tidal breathing protocol with the use of a standardized breath-condensate collector which was stored at −80 C prior to sampling (RTube, Austin, T, USA).
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
153. An Exposure Study Linking Environmental and Human Biological Parameter Measurements, with a Focus on Th1/Th2 Cytokine Expression
Methods / analytical studyAppended client-supplied record
Citation: M Stiegel - 2014 - cdr.lib.unc.edu. An Exposure Study Linking Environmental and Human Biological Parameter Measurements, with a Focus on Th1/Th2 Cytokine Expression. Citation link
RTube use: condensate samples were collected using a RTubeTM (Respiratory Research, Inc., Austin Texas) exhaled breath condensate … The RTube was removed from the sleeve after collection
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
154. Methodological and physiological aspects of exhaled breath analysis
Methods / analytical studyAppended client-supplied record
Citation: A Bikov - 2014 - repo.lib.semmelweis.hu. Methodological and physiological aspects of exhaled breath analysis. Citation link
RTube use: breathing, small droplets arise from the ALF and condense … into the forming condensate fluid. However, exhaled breath … condensate was collected during tidal breathing using Rtube (
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
2013
155. Relationship between nitrate concentration in exhaled breath condensate and indoor air quality-ENVIRH study
Research studyAppended client-supplied record
Citation: I Caires, P Martins, J Marques, J Belo… - … Congress-New Ways …, 2013 - repositorio.insa.pt. Relationship between nitrate concentration in exhaled breath condensate and indoor air quality-ENVIRH study. Citation link
RTube use: (NO), namely nitrates (NO3-) in exhaled breath condensate (EBC), is a good biomarker of … EBC were collected, using a disposable device (RTube), from a group of children in preschool
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
156. Exhaled breath condensate eicosanoid levels associate with asthma and its severity
Research studyAppended client-supplied record
Citation: S Kazani, A Planaguma, E Ono, M Bonini… - Journal of allergy and …, 2013 - Elsevier. Exhaled breath condensate eicosanoid levels associate with asthma and its severity. Citation link
RTube use: EBC was collected once from each enrolled study participant by using recommended methods with an RTube (Respiratory Research, Austin, Tex). Participants were required to
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
157. Articles in PresS. Am J Physiol Lung Cell Mol Physiol (January 25, 2013). doi: 10.1152/ajplung. 00344.2012
Research studyAppended client-supplied record
Citation: CR Esther Jr, BM Olsen, FC Lin, J Fine, RC Boucher - 2013 - journals.physiology.org. Articles in PresS. Am J Physiol Lung Cell Mol Physiol (January 25, 2013). doi: 10.1152/ajplung. 00344.2012. Citation link
RTube use: use of exhaled breath 61 condensate (EBC) as an … the RTube (Respiratory Research, 103 Charlottesville, VA) as previously described (15). Briefly, subjects exhaled through the RTube
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
158. Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high …
Protocol / study designAppended client-supplied record
Citation: DS Martin, ET Gilbert-Kawai, PM Meale… - Contemporary Clinical …, 2013 - Elsevier. Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high …. Citation link
RTube use: Exhaled breath condensate was collected in a non-invasive manner by … (RTube®, Respiratory Research, Inc., Charlottesville, VA, USA). Two 1 ml aliquots of exhaled breath condensate
Study focus: Protocol / study design involving RTube/EBC product use as represented in the linked source excerpt.
159. Environment and health in children day care centers
Research studyAppended client-supplied record
Citation: N Neuparth, AL Papoila, C Pedro… - … and health in …, 2013 - repositorio.ipsantarem.pt. Environment and health in children day care centers. Citation link
RTube use: Airway inflammation markers (condensate pH and total nitrites/nitrates) were measured in breath condensate collected during 15 minutes using an RTube (Respiratory Research Inc.,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2012
160. Exhaled breath condensate—an overview
Research studyAppended client-supplied record
Citation: MD Davis, A Montpetit, J Hunt - … and allergy clinics of North America, 2012 - ncbi.nlm.nih.gov. Exhaled breath condensate—an overview. Citation link
RTube use: RTube Respiratory Research, USA More total EBC collections performed using RTube than … requires optional cooling unit, otherwise condensation temperature is chosen by cooling
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
161. Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients
Research studyAppended client-supplied record
Citation: AR Koczulla, S Noeske, C Herr, J Koepke, RA Jörres… - Respiratory …, 2012 - Elsevier. Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients. Citation link
RTube use: Measurement of exhaled breath condensate (EBC) is a noninvasive method to investigate … with exacerbations of COPD was collected with the RTube™ device. AAT from EBC and
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
162. Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS
Research studyAppended client-supplied record
Citation: M Fumagalli, F Ferrari, M Luisetti, J Stolk… - International journal of …, 2012 - mdpi.com. Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS. Citation link
RTube use: Exhaled breath condensate was collected by using the RTube kit (Respiratory Research Inc., Austin, TX, USA) according to ATS/ERS guidelines [21]. The volume of condensate
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
163. Profile of eicosanoids in breath condensate in asthma and COPD
Research studyAppended client-supplied record
Citation: LG Fritscher, M Post, MT Rodrigues… - Journal of breath …, 2012 - iopscience.iop.org. Profile of eicosanoids in breath condensate in asthma and COPD. Citation link
RTube use: EBC was collected by using a commercial device specifically designed to collect breath condensate that comes with a cooling sleeve that is stored in a freezer (RTube®, Respiratory
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
164. Plasma and exhaled breath condensate nitrite–nitrate level in relation to environmental exposures in adults in the EGEA study
Research studyAppended client-supplied record
Citation: M Rava, R Varraso, B Decoster, H Huyvaert… - Nitric Oxide, 2012 - Elsevier. Plasma and exhaled breath condensate nitrite–nitrate level in relation to environmental exposures in adults in the EGEA study. Citation link
RTube use: EBC was collected with an RTube (TM) according to standardized methods. Briefly, the RTube (TM) was rinsed with deionized water and dried thoroughly. Subjects breathed orally at
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
165. Asthma randomized trial of indoor wood smoke (ARTIS): rationale and methods
Methods / analytical studyAppended client-supplied record
Citation: CW Noonan, TJ Ward - Contemporary clinical trials, 2012 - Elsevier. Asthma randomized trial of indoor wood smoke (ARTIS): rationale and methods. Citation link
RTube use: condensate (EBC) samples per winter were collected using an Rtube breath condensate … over the outside of a disposable vertical condensation/collection tube and connected to two-
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
166. Relationship between exhaled nitric oxide and exposure to low-level environmental tobacco smoke in children with asthma on inhaled corticosteroids
Research studyAppended client-supplied record
Citation: E de la Riva-Velasco, S Krishnan, AJ Dozor - Journal of Asthma, 2012 - Taylor & Francis. Relationship between exhaled nitric oxide and exposure to low-level environmental tobacco smoke in children with asthma on inhaled corticosteroids. Citation link
RTube use: condensate (EBC) was collected according to the ERS/ATS guidelines (Citation39) with the RTube… PH in expired breath condensate of patients with inflammatory airway diseases. Am J
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2011
167. Exhaled breath condensate sampling is not a new method for detection of respiratory viruses
Methods / analytical studyAppended client-supplied record
Citation: L Houspie, S De Coster, E Keyaerts, P Narongsack… - Virology journal, 2011 - Springer. Exhaled breath condensate sampling is not a new method for detection of respiratory viruses. Citation link
RTube use: In the fall and first half of the winter of 2009/2010, 32 condensates were collected from … condensates were collected with the cooler chilled at -20C. For 13 out of 32 collections, the RTube
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
168. Evaluation of exhaled breath condensate pH as a biomarker for COPD
Research studyAppended client-supplied record
Citation: W MacNee, SI Rennard, JF Hunt, LD Edwards… - Respiratory …, 2011 - Elsevier. Evaluation of exhaled breath condensate pH as a biomarker for COPD. Citation link
RTube use: John Hunt, MD: JH is a co-founder of Respiratory Research, Inc., which develops exhaled breath assays and manufactures the RTubes used in this study. Respiratory Research has
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
169. Day To Day Variability In Feno, Exhaled Breath Condensate Ph And Fev1/FVC Among 9-10 Year Old Urban Children
Conference abstractAppended client-supplied record
Citation: F Hafeez, BB Obeng, T Li, J Cai, C Olivo… - C35. INSIGHTS INTO …, 2011 - atsjournals.org. Day To Day Variability In Feno, Exhaled Breath Condensate Ph And Fev1/FVC Among 9-10 Year Old Urban Children. Citation link
RTube use: Rationale: Fractional exhaled NO (FeNO), exhaled breath condensate (EBC) pH and lung … EBC was collected using RTubes and pH was measured after de-aeration. Pulmonary
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
170. Comparison of two devices and two breathing patterns for exhaled breath condensate sampling
Research studyAppended client-supplied record
Citation: AR Koczulla, E Hüttmann, T Greulich, A Hattesohl… - 2011 - Eur Respiratory Soc. Comparison of two devices and two breathing patterns for exhaled breath condensate sampling. Citation link
RTube use: Results: RTube provided a higher sample volume compared to the EcoScreen. Hyperventilation yielded higher volumes than tidal breathing. Neither devices nor breathing patterns
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
171. Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD
Methods / analytical studyAppended client-supplied record
Citation: T Zakharkina, AR KOCZULLA, O Mardanova… - …, 2011 - Wiley Online Library. Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD. Citation link
RTube use: condensate was collected according to the published ERS guidelines. In short, EBC samples were collected during 10 min of quiet breathing through a single-use disposable RTube
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
172. A new approach to study exhaled proteins as potential biomarkers for asthma
Research studyAppended client-supplied record
Citation: K Bloemen, R Van Den Heuvel… - Clinical & …, 2011 - Wiley Online Library. A new approach to study exhaled proteins as potential biomarkers for asthma. Citation link
RTube use: Recently, various studies reported on the analysis of exhaled breath condensate (EBC) in … in an uncoated RTube. A second EBC sample was collected for 10 min breathing in an RTube
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
173. Exercise changes volatiles in exhaled breath assessed by an electronic nose
Research studyAppended client-supplied record
Citation: A Bikov, Z Lazar, K Schandl, B Antus… - Acta Physiologica …, 2011 - akjournals.com. Exercise changes volatiles in exhaled breath assessed by an electronic nose. Citation link
RTube use: for the alkalization of the exhaled breath condensate (EBC) fluid following physical exercise. … Exhaled breath condensate was collected with a commercially available condenser (RTube
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
174. Discrimination between COPD patients with and without alpha 1‐antitrypsin deficiency using an electronic nose
Research studyAppended client-supplied record
Citation: ADM Hattesohl, RA JÖRres, H Dressel, S Schmid… - …, 2011 - Wiley Online Library. Discrimination between COPD patients with and without alpha 1‐antitrypsin deficiency using an electronic nose. Citation link
RTube use: Methods: Exhaled breath condensate and pure exhaled … Exhaled breath condensate and pure exhaled breath were … a single-use disposable RTube device (Respiratory Research Inc.,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
175. RESIDENTIAL WOOD SMOKE PM2.5 AND A BIOMARKER OF OXIDATIVE STRESS IN ASTHMATIC CHILDREN
Conference abstractAppended client-supplied record
Citation: M McNamara, E Semmens, T Ward… - ISEE Conference …, 2011 - ehp.niehs.nih.gov. RESIDENTIAL WOOD SMOKE PM2.5 AND A BIOMARKER OF OXIDATIVE STRESS IN ASTHMATIC CHILDREN. Citation link
RTube use: Background and Aims: Exhaled breath condensate (EBC) is a biofluid that can be analyzed … EBC samples were collected using Rtubes (Respiratory Research) and were analyzed for 8-
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
176. The Effect Of Augmentation Therapy On Systemic And Pulmonary Inflammation Markers In Alpha1-Antitrypsin Deficiency Patients
Conference abstractAppended client-supplied record
Citation: S Schmid, S Noeske, A Hattesohl… - … AND MODELS OF …, 2011 - atsjournals.org. The Effect Of Augmentation Therapy On Systemic And Pulmonary Inflammation Markers In Alpha1-Antitrypsin Deficiency Patients. Citation link
RTube use: the blood and Exhaled Breath Condensate (EBC) and their immediate reaction on substitution of AAT. Methods: EBC from all individuals was collected with the RTube device by gently
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
177. Windsor, Ontario exposure assessment study: design and methods validation of personal, indoor, and outdoor air pollution monitoring
Protocol / study designAppended client-supplied record
Citation: AJ Wheeler, X Xu, R Kulka, H You… - Journal of the Air & …, 2011 - Taylor & Francis. Windsor, Ontario exposure assessment study: design and methods validation of personal, indoor, and outdoor air pollution monitoring. Citation link
RTube use: , an exhaled breath condensate sample was collected using an RTube (Respiratory Research… Approximately 1 mL of breath condensate was collected. The condensed breath was then
Study focus: Protocol / study design involving RTube/EBC product use as represented in the linked source excerpt.
178. Biomarkers Of Airway Inflammation In Asthmatic Children On Inhaled Corticosteroid Therapy Exposed To Low Levels Of Environmental Tobacco Smoke
Conference abstractAppended client-supplied record
Citation: E De La Riva-Velasco, S Krishnan… - C106. PEDIATRIC …, 2011 - atsjournals.org. Biomarkers Of Airway Inflammation In Asthmatic Children On Inhaled Corticosteroid Therapy Exposed To Low Levels Of Environmental Tobacco Smoke. Citation link
RTube use: Exhaled breath condensate (EBC) was collected using the RTube technique, and tested for pH and ammonia concentration. Thirty three subjects were enrolled, including twenty four
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
179. Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity
Research studyAppended client-supplied record
Citation: KJ Reszka, L Sallans, S Macha, K Brown… - … of Pharmacology and …, 2011 - ASPET. Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity. Citation link
RTube use: a single-use disposable RTube collector (Respiratory Research, Inc… of exhaled breath condensates from asthmatic patients who … metabolites, we pooled condensates from three different
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
180. Atopy, Asthma And The Nitrite-Nitrate-No Pathway Among Adults From The Egea Study
Conference abstractAppended client-supplied record
Citation: M Rava, F Kauffmann, H Huyvaert… - C51. ASTHMA …, 2011 - atsjournals.org. Atopy, Asthma And The Nitrite-Nitrate-No Pathway Among Adults From The Egea Study. Citation link
RTube use: EBC was collected using RTube™. Total NO2-NO3 (converted nitrate plus nitrite, Griess reaction) was expressed as µM in plasma and as µmol/µg in EBC (NO -NO divided by
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
2010
181. Ambient temperature impacts on pH of exhaled breath condensate
Research studyAppended client-supplied record
Citation: AR Koczulla, S Noeske, C Herr, F Dette… - …, 2010 - Wiley Online Library. Ambient temperature impacts on pH of exhaled breath condensate. Citation link
RTube use: Exhaled breath condensate samples were collected during 10 min of quiet breathing through a single-use disposable RTube device (Respiratory Research, Inc., USA) using a nose clip
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
182. Total Nitrate/Nitrite levels in plasma and exhaled breath condensate: associations with age and smoking according to asthma among 1159 adults from the EGEA study
Conference abstractAppended client-supplied record
Citation: R Nadif, B Decoster, H Huyvaert, G Briand… - B47. ASTHMA …, 2010 - atsjournals.org. Total Nitrate/Nitrite levels in plasma and exhaled breath condensate: associations with age and smoking according to asthma among 1159 adults from the EGEA study. Citation link
RTube use: Methods–EBC was collected according to standardized method using RTube™. In plasma and EBC, total NO2-NO3 (converted nitrate plus nitrite) was measured by using the Griess
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
183. An Electronic Nose Distinguishes The Exhaled Breath Condensates Obtained By Two Different Devices And Two Different Breath Patterns
Conference abstractAppended client-supplied record
Citation: S Noeske, A Hattesohl, R Jörres, T Greulich… - … AND AEROSOLS IN …, 2010 - atsjournals.org. An Electronic Nose Distinguishes The Exhaled Breath Condensates Obtained By Two Different Devices And Two Different Breath Patterns. Citation link
RTube use: and distinguish the VOCs in exhaled breath condensate (EBC) of healthy subjects using two different devices for obtaining EBC. The portable RTube® (Respiratory Research,USA) and
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
184. Analysis By SELDI-TOF Of Exhaled Breath Condensate May Discriminate COPD From Healthy Subjects
Conference abstractAppended client-supplied record
Citation: M Fumagalli, D Capuano, J Stolk… - … AND LUNG DISEASE …, 2010 - atsjournals.org. Analysis By SELDI-TOF Of Exhaled Breath Condensate May Discriminate COPD From Healthy Subjects. Citation link
RTube use: is currently increasing, in particular Exhaled Breath Condensate (EBC), a liquid phase that … -TOF MS to EBCs collected with a RTube from 80 subjects grouped into four distinct groups ie
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
185. Levels of exhaled breath condensate pH and fractional exhaled nitric oxide in retired coal miners
Research studyAppended client-supplied record
Citation: JS Lee, JH Shin, JO Lee, KM Lee, JH Kim… - Toxicological …, 2010 - Springer. Levels of exhaled breath condensate pH and fractional exhaled nitric oxide in retired coal miners. Citation link
RTube use: Exhaled breath condensate was collected during oral tidal breathing using the Rtube … The condensate was transferred from the collection tube into cryogenic vials and stored at −80
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
186. Identification of intrinsic airway acidification in pulmonary tuberculosis
Research studyAppended client-supplied record
Citation: L Ngamtrakulpanit, Y Yu, A Adjei, G Amoah… - Global journal of …, 2010 - ncbi.nlm.nih.gov. Identification of intrinsic airway acidification in pulmonary tuberculosis. Citation link
RTube use: Exhaled breath condensate acidification reflects the presence … We collected exhaled breath condensate, and assayed for … EBC was collected using the RTube system (Respiratory
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
187. The role of purinergic system in airway diseases
Research studyAppended client-supplied record
Citation: Z Lázár - Citeseer Added:. The role of purinergic system in airway diseases. Citation link
RTube use: The chiller tube of the RTube was held at -80ºC before condensate collection. EBC samples were stored at -80ºC in DNA/RNA LoBind microcentrifuge tubes (Eppendorf AG; Hamburg,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
188. Lung Cancer Does Not Influence Exhaled Breath Condensate PH In COPD Patients
Conference abstractAppended client-supplied record
Citation: A Bikov, Z Lázár, N Gyulai, E Őri, D Kovács… - B62. LUNG CANCER …, 2010 - atsjournals.org. Lung Cancer Does Not Influence Exhaled Breath Condensate PH In COPD Patients. Citation link
RTube use: , as shown by a decrease in exhaled breath condensate (EBC) pH in these patients. In … from subjects wearing a nose clip using Rtube (Respiratory Research, Charlottesville, USA)
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
189. Содержание интерлейкина-8, растворимых молекул адгезии и молекул гистосовместимости I класса у больных хронической обструктивной болезнью легких …
Research studyAppended client-supplied record
Citation: НИ Кубышева, ЛБ Постникова, ВВ Новиков… - Иммунопатология …, 2010 - elibrary.ru. Содержание интерлейкина-8, растворимых молекул адгезии и молекул гистосовместимости I класса у больных хронической обструктивной болезнью легких …. Citation link
RTube use: - 1) and molecules HLA class I in a condensate of exhaled air at COPD patients. Data suggest … ) осуществляли с помощью специальной системы RTUBE™ (Respiratory Research Inc,
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2009
190. Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
Research studyAppended client-supplied record
Citation: R Koczulla, S Dragonieri, R Schot, R Bals, SA Gauw… - Respiratory …, 2009 - Springer. Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients. Citation link
RTube use: RTube and ECoScreen in the HC group. To study the reproducibility of EBC pH for ECoScreen and RTube, … Our results on the performance of the RTube and ECoScreen for pH analysis
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
191. Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers
Research studyAppended client-supplied record
Citation: AR Koczulla, S Noeske, C Herr, RA Jörres, H Römmelt… - Respiration, 2009 - karger.com. Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers. Citation link
RTube use: Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that … EBC was obtained during 10 min tidal breathing with a cooled RTube™. pH was determined
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
192. Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices
Research studyAppended client-supplied record
Citation: F Hoffmeyer, M Raulf-Heimsoth, V Harth… - BMC pulmonary …, 2009 - Springer. Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices. Citation link
RTube use: pH was demonstrated using RTube at a starting temperature … A warm-up during condensation is observed using RTube or … limitations as exhaled breath condensates on a teflon coated
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
193. An electronic nose distinguishes the exhaled breath condensates of alpha-1-antitrypsin deficiency patients and healthy controls
Conference abstractAppended client-supplied record
Citation: AR Koczulla, A Hattesohl, S Noeske… - …, 2009 - thieme-connect.com. An electronic nose distinguishes the exhaled breath condensates of alpha-1-antitrypsin deficiency patients and healthy controls. Citation link
RTube use: analyze and distinguish the VOCs in exhaled breath condensate (EBC) of patients with α 1 -… from ten HCs and ten AATD patients with the RTube by ten minutes of tidal breathing. 250µl
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
194. Distinguishing the exhaled breath condensates of two pa-tient groups with an electronic nose
Conference abstractAppended client-supplied record
Citation: A Hattesohl, S Noeske, R Bals… - German Conference … - informatik.uni-halle.de. Distinguishing the exhaled breath condensates of two pa-tient groups with an electronic nose. Citation link
RTube use: analyze and distinguish the VOCs in exhaled breath condensate (EBC) of patients with α1-… The EBC was collected from ten HCs and ten AATD patients with the RTube [Res] by ten
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
195. A longitudinal study to assess the presence of manganese in blood and exhaled breath condensate following acute inhalation exposure to welding fumes
Thesis / dissertationAppended client-supplied record
Citation: JD Richman - 2009 - search.proquest.com. A longitudinal study to assess the presence of manganese in blood and exhaled breath condensate following acute inhalation exposure to welding fumes. Citation link
RTube use: Temperature is not controlled during EBC collection with the Rtube, because it uses an … are much more expensive than the Rtube making the use of Rtubes more feasible for a small-
Study focus: Thesis / dissertation involving RTube/EBC product use as represented in the linked source excerpt.
196. Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients
Methods / analytical studyAppended client-supplied record
Citation: W Han, T Wang, AA Reilly, SM Keller, SD Spivack - Respiratory Research, 2009 - Springer. Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients. Citation link
RTube use: DNA methylation in exhaled breath condensate, we applied our … , and adapted it to exhaled breath condensate (EBC) from lung … EBC is collected in a handheld, disposable RTube ®
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
197. Pulmonary and Systemic Increase of alpha 1-Antitrypsin in Acute Exacerbated COPD Patients.
Conference abstractAppended client-supplied record
Citation: AR Koczulla, S Noeske, C Herr… - A39. COPD …, 2009 - atsjournals.org. Pulmonary and Systemic Increase of alpha 1-Antitrypsin in Acute Exacerbated COPD Patients.. Citation link
RTube use: Measurement of exhaled breath condensate (EBC) is a non invasive method to investigate … Methods: EBC from all individuals was collected with the RTube™ device by gently breathing
Study focus: Conference abstract involving RTube/EBC product use as represented in the linked source excerpt.
198. Nitric oxide in airway inflammation
Research studyAppended client-supplied record
Citation: J Liu - 2009 - unsworks.unsw.edu.au. Nitric oxide in airway inflammation. Citation link
RTube use: ® than siliconised glass tubes or RTube® but it gave factitiously … Relationship between exhaled breath condensate volume … Exhaled breath condensate as a method of sampling airway
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
199. Breathe in, breathe out: using the airway to combat cancer (Proceedings)
Research studyAppended client-supplied record
Citation: KA Selting - 2009 - dvm360.com. Breathe in, breathe out: using the airway to combat cancer (Proceedings). Citation link
RTube use: After 15-20 minutes of normal breathing, condensate was collected from the inner chamber … The RTube® is a unique tool used for EBC investigation and evaluation that may be able to
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
200. Biomarkers obtained by non-invasive methods in patients with COPD: where do we stand, what do we expect?
Methods / analytical studyAppended client-supplied record
Citation: G Hillas, S Loukides, K Kostikas… - Current medicinal …, 2009 - ingentaconnect.com. Biomarkers obtained by non-invasive methods in patients with COPD: where do we stand, what do we expect?. Citation link
RTube use: The commonly used Exhaled Breath Condensate (EBC) methodologies in COPD patients … portable devices using an aluminum cylinder for cooling (RTube, Respiratory Research Inc.,
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
2008
201. Temperature changes in exhaled breath condensate collection devices affect observed acetone concentrations
Research studyAppended client-supplied record
Citation: BR Loyola, A Bhushan, M Schivo… - Journal of Breath …, 2008 - iopscience.iop.org. Temperature changes in exhaled breath condensate collection devices affect observed acetone concentrations. Citation link
RTube use: measured during breath condensate collection, using the modified collection tubes containing thermocouples. Prior to condensate collection trials, we placed the RTube passivecooling
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
202. Adenosine triphosphate in exhaled breath condensate of healthy subjects and patients with chronic obstructive pulmonary disease
Research studyAppended client-supplied record
Citation: Z Lázár, E Huszar, T Kullmann, I Barta, B Antus… - Inflammation …, 2008 - Springer. Adenosine triphosphate in exhaled breath condensate of healthy subjects and patients with chronic obstructive pulmonary disease. Citation link
RTube use: We aimed to measure breath condensate ATP concentration in health and disease. EBC … In case of the RTube, the chiller tube was held at –70 ºC before condensate collection. EBC
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
203. Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to α1-antitrypsin deficiency
Research studyAppended client-supplied record
Citation: M Fumagalli, L Dolcini, A Sala, J Stolk, L Fregonese… - Journal of …, 2008 - Elsevier. Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to α1-antitrypsin deficiency. Citation link
RTube use: condensate was collected using an RTube kit (… condense along the walls of the tube. Subjects were asked to breath in this device while wearing a nose clip. The volume of condensate
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
204. Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
Research studyAppended client-supplied record
Citation: O Roca, S Gómez-Ollés, MJ Cruz, X Muñoz… - Critical Care, 2008 - Springer. Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis. Citation link
RTube use: In otherwise healthy patients undergoing lung resection for cancer, the mean EBC pH obtained using RTubes™ was 7.8 [17]. Another study of patients undergoing cardiothoracic
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
205. Airway responsiveness and inflammation in adolescent elite swimmers
Research studyAppended client-supplied record
Citation: L Pedersen, TK Lund, PJ Barnes, SA Kharitonov… - Journal of allergy and …, 2008 - Elsevier. Airway responsiveness and inflammation in adolescent elite swimmers. Citation link
RTube use: , 22 and at visit B we collected exhaled breath condensate (EBC) followed by a eucapnic voluntary … Exhaled breath condensate samples were collected by using RTubes (Respiratory
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
206. Jill M Ferdinands*, Carol A Gotway Crawford2, Roby Greenwald3
Research studyAppended client-supplied record
Citation: D Van Sickle, E Hunter… - Environmental …, 2008 - ehjournal.biomedcentral.com. Jill M Ferdinands*, Carol A Gotway Crawford2, Roby Greenwald3. Citation link
RTube use: ), and collected 5-minute breath condensate samples (Rtube®, Respiratory Research, Charlottesville, VA) from each participant. Breath condensate sample were collected during tidal
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
207. Pretreatment with albuterol versus montelukast for exercise‐induced bronchospasm in children
Research studyAppended client-supplied record
Citation: HH Raissy, M Harkins, F Kelly… - … : The Journal of Human …, 2008 - Wiley Online Library. Pretreatment with albuterol versus montelukast for exercise‐induced bronchospasm in children. Citation link
RTube use: Measurement of exhaled breath condensate was performed at the … condensate were collected at the beginning of study visits 1 and 2 with use of a disposable collection kit (RTube;
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
208. EXHALED BREATH-GENERATED AEROSOLS OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH ACTIVE P ULMONARY TUBERCULOSIS DURING …
Research studyAppended client-supplied record
Citation: H Kawada, M Yamazato, Y Shinozawa… - Kekkaku …, 2008 - jstage.jst.go.jp. EXHALED BREATH-GENERATED AEROSOLS OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH ACTIVE P ULMONARY TUBERCULOSIS DURING …. Citation link
RTube use: RTubeは,一 方向の気流を確保する必要上,回 路内に スリットが… We also prepared an exhaled breath condensate by cooling … The exhaled breath condensates were also negative in 24
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
209. Mesure de l'inflammation pulmonaire dans la mucoviscidose
Research studyAppended client-supplied record
Citation: M Fayon, R Chiron, M Abely - Revue des maladies respiratoires, 2008 - Elsevier. Mesure de l'inflammation pulmonaire dans la mucoviscidose. Citation link
RTube use: exhaled breath condensate) est obtenu par condensation de … le patient et la chambre de condensation. Il existe plusieurs … que les tubes en téflon (Rtube) qui sont moins utilisés dans
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2007
210. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices
Methods / analytical studyAppended client-supplied record
Citation: L Prieto, A Ferrer, J Palop, J Domenech, R Llusar… - Respiratory …, 2007 - Elsevier. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Citation link
RTube use: condensate (EBC) collections, using the RTube collection system and the EcoScreen condenser. EBC pH was measured immediately after collection and after storage at −80 C for 8
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
211. Exhaled breath condensate: an overview
Research studyAppended client-supplied record
Citation: J Hunt - Immunology and allergy clinics of North America, 2007 - Elsevier. Exhaled breath condensate: an overview. Citation link
RTube use: RTube Respiratory Research, USA More total EBC collections performed using RTube than … requires optional cooling unit, otherwise condensation temperature is chosen by cooling
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
212. Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis
Research studyAppended client-supplied record
Citation: EH Baker, N Clark, AL Brennan… - Journal of applied …, 2007 - journals.physiology.org. Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis. Citation link
RTube use: was collected by exhalation through a one-way valve into a cooled, 22.2-cm-long RTube (… Retrieved condensate was stored at −20C. Plastics other than RTubes were washed in
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
213. Determinants of variability of protein content, volume and pH of exhaled breath condensate
Research studyAppended client-supplied record
Citation: K Bloemen, G Lissens, K Desager, G Schoeters - Respiratory medicine, 2007 - Elsevier. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Citation link
RTube use: Exhaled breath condensate was collected using a RTube (Respiratory Research, Inc). The … the condensate was measured immediately using a calibrated 1 ml pipette. The condensate
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
214. Exhaled breath condensate mediators in mechanically ventilated brain-injured patients with no acute lung injury are mostly related to markers of systemic …
Research studyAppended client-supplied record
Citation: I Korovesi, E Papadomichelakis, O Livaditi… - Critical Care, 2007 - Springer. Exhaled breath condensate mediators in mechanically ventilated brain-injured patients with no acute lung injury are mostly related to markers of systemic …. Citation link
RTube use: Methods Patients were ventilated with 8 ml/kg tidal volume and were put either on PEEP= 0 (ZEEP, n= 12) or 8 cmH 2 O (PEEP, n= 15). EBC was collected using the RTube device (
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
215. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics
Research studyAppended client-supplied record
Citation: S Komakula, S Khatri, J Mermis, S Savill, S Haque… - Respiratory …, 2007 - Springer. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Citation link
RTube use: Exhaled breath condensate (EBC) was collected using the Rtube, a non-invasive breath condensate collection device (Charlottesville, VA). To produce the condensate we used a metal
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
216. Exhaled breath biomarkers in asthmatic children
Research studyAppended client-supplied record
Citation: M Corradi, C Zinelli, C Caffarelli - Inflammation & Allergy-Drug …, 2007 - ingentaconnect.com. Exhaled breath biomarkers in asthmatic children. Citation link
RTube use: markers in both exhaled breath and condensate have emerged as a possible non invasive … A comparison between two different devices; RTubes and EcoScreen, for collecting EBC
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2006
217. Exhaled breath condensate pH and childhood asthma: unselected birth cohort study
Research studyAppended client-supplied record
Citation: NC Nicolaou, LA Lowe, CS Murray… - American journal of …, 2006 - atsjournals.org. Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. Citation link
RTube use: Methods: Within the context of a prospective population-based birth cohort, EBC was collected from 630 children at age 8 yr using the RTube (pH measured after deaeration with argon).
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2005
218. Exhaled breath condensate pH assays are not influenced by oral ammonia
Methods / analytical studyAppended client-supplied record
Citation: K Wells, J Vaughan, TN Pajewski, S Hom… - Thorax, 2005 - thorax.bmj.com. Exhaled breath condensate pH assays are not influenced by oral ammonia. Citation link
RTube use: Exhaled breath condensate was collected during oral tidal breathing using the RTube™ EBC … For intubated collections the RTube condenser was attached early in the exhalation circuit
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
219. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children
Research studyAppended client-supplied record
Citation: T Leung, GWK Wong, FWS Ko, C Li, E Yung… - International archives of …, 2005 - karger.com. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Citation link
RTube use: in our recent study in which EBC was collected using RTubes [18, 26]. We believe that our results … In the present study, disposable RTubes was used to collect EBC as condensed liquid
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2004
220. A Comparison of Exhaled Breath Nitric Oxide Between Old and Young Individuals
Research studyAppended client-supplied record
Citation: RL Gordon - 2004 - core.ac.uk. A Comparison of Exhaled Breath Nitric Oxide Between Old and Young Individuals. Citation link
RTube use: condensate collection and deaeration of the condensate were performed as has been described in the literature by using the RTube™ … was taken to be the pH of the condensate for that
Study focus: Research study involving RTube/EBC product use as represented in the linked source excerpt.
2003
221. Exhaled breath condensate pH is a robust and reproducible assay of airway acidity
Methods / analytical studyAppended client-supplied record
Citation: J Vaughan, L Ngamtrakulpanit… - European …, 2003 - Eur Respiratory Soc. Exhaled breath condensate pH is a robust and reproducible assay of airway acidity. Citation link
RTube use: condensate collection was performed using the RTube TM … rapid breathing through the RTube condenser. ETCO 2 values … min using the standard RTube condensation equipment, with
Study focus: Methods / analytical study involving RTube/EBC product use as represented in the linked source excerpt.
Study List
1. Highly sensitive multiplex assay of interleukins in exhaled breath condensate from children with bronchial asthma: diagnostic significance of IL-13 and IL-17A
Citation: Smolnikova, M. V., Gorbacheva, N. N., et al. (2025). Highly sensitive multiplex assay of interleukins in exhaled breath condensate from children with bronchial asthma: Diagnostic significance of IL-13 and IL-17A. Russian Journal of Immunology.
RTube use: EBC was collected with the RTube device from children with bronchial asthma; samples were concentrated and assayed for interleukins, with IL-13 and IL-17A evaluated as asthma-related inflammatory markers.
Study focus: Pediatric asthma biomarker study using RTube-collected condensate for multiplex cytokine profiling.
2. Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19
Citation: Gade, I. L., Bodilsen, J., Mariager, T., Hertz, S., et al. (2025). Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19. Journal of Breath Research.
RTube use: RTubes were used to collect EBC from 28 hospitalized COVID-19 patients at admission and discharge; condensate proteins were analyzed by bottom-up proteomics.
Study focus: COVID-19 respiratory proteomics using serial RTube EBC sampling.
3. Volatile organic compound and proteomics data from the same exhaled breath condensate sample
Citation: Schrader, S. E., Hansen, J. R., O’Bryon, I., et al. (2025). Volatile organic compound and proteomics data from the same exhaled breath condensate sample. Journal of Breath Research.
RTube use: The study used the RTube for EBC capture and incorporated RTube water blanks as negative controls, pushing water through and sloshing it within the collection chamber to quantify device/background contribution.
Study focus: Method/data study showing combined VOC and proteomic measurement from the same RTube-collected condensate sample.
4. Pentadecanoic acid attenuates pulmonary fibrosis by inhibiting Smad2/3 signaling
Citation: Kim, Y., Han, Y., Jeon, G. S., Song, J. W., et al. (2025). Pentadecanoic acid attenuates pulmonary fibrosis by inhibiting Smad2/3 signaling. American Journal of Respiratory and Critical Care Medicine.
RTube use: EBC from patients with idiopathic pulmonary fibrosis was collected using the RTube condenser and analyzed for C15:0/pentadecanoic-acid-associated signals.
Study focus: Pulmonary fibrosis biomarker/mechanism study linking RTube EBC metabolite measurements to fibrotic signaling biology.
5. Fuel-Free Rolosense: Viral sensing using diffusional particle tracking
Citation: Piranej, S., Jackson, K., Zhang, L., Kæstel-Hansen, J., et al. (2025). Fuel-Free Rolosense: Viral sensing using diffusional particle tracking. ACS Publications.
RTube use: The RTube breath condensate collection device was purchased from Respiratory Research and used as the EBC sampling platform for testing viral-sensing assay behavior in breath condensate.
Study focus: Analytical biosensor study using RTube-collected breath condensate as a biological matrix for viral detection.
6. The detection of cannabinoids in breath after ingestion of cannabis-infused edibles
Citation: Berry, J. L., Brooks-Russell, A., et al. (2025). The detection of cannabinoids in breath after ingestion of cannabis-infused edibles. Journal of Analytical Toxicology.
RTube use: A participant subset used an RTube condensate device to collect exhaled breath aerosols/EBC after edible cannabis ingestion; THC and related cannabinoids were assessed in the breath matrix.
Study focus: Forensic/toxicology study testing whether RTube EBC can capture cannabinoids after oral cannabis exposure.
7. A handheld biofluorometric system for acetone detection in exhaled breath condensates
Citation: Zhang, G., Ichikawa, K., Iitani, K., Iwasaki, Y., et al. (2025). A handheld biofluorometric system for acetone detection in exhaled breath condensates. Analyst.
RTube use: Healthy participants collected EBC using an RTube after maintaining constant breathing for 8 minutes while sedentary; the condensate was tested with a handheld biofluorometric acetone system.
Study focus: Point-of-care analytical chemistry study using RTube EBC to measure acetone in breath condensate.
8. Linking volatile metabolites from bacterial pathogens to exhaled breath condensate of people with cystic fibrosis
Citation: Karunarathne, P. H., Bridges, C., Remisoski, L., et al. (2025). Linking volatile metabolites from bacterial pathogens to exhaled breath condensate of people with cystic fibrosis. Microbiology Research.
RTube use: EBC was collected through an RTube with an added filter/mouthpiece configuration; after clearing the device, condensate volumes ranged roughly from 500 μL upward for downstream volatile-metabolite comparisons.
Study focus: Cystic fibrosis breathomics study connecting pathogen-derived volatile metabolites with RTube EBC profiles.
9. Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells
Citation: Pedklang, N., Navasumrit, P., Chompoobut, C., et al. (2025). Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells. International Journal of Hygiene and Environmental Health.
RTube use: Human EBC was collected as the noninvasive airway matrix for measuring DNA damage and mitochondrial/telomere-related endpoints associated with traffic-related particulate exposure; indexed RTube usage identifies the collection platform.
Study focus: Environmental exposure study using breath condensate genomics markers to assess particulate-pollution effects.
10. The role of myristic acid in the pathogenesis of pulmonary fibrosis
Citation: Han, Y. J., Kim, Y., Jeon, G. S., Song, J. W., et al. (2025). The role of myristic acid in the pathogenesis of pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine.
RTube use: EBC samples from pulmonary fibrosis patients were collected using the RTube condenser and analyzed for myristic-acid-related metabolite signals.
Study focus: Pulmonary fibrosis metabolite study using RTube EBC to connect fatty-acid signatures with disease pathogenesis.
11. Occupational exposure to aerosols in two French airports: multi-year lung function changes
Citation: Touri, L., Tarantini, A., Suehs, C. E., Nogué, E., et al. (2025). Occupational exposure to aerosols in two French airports: Multi-year lung function changes. Annals of Work Exposures and Health.
RTube use: EBC from airport workers was collected into RTubes and immediately frozen at −20 °C in the collecting portions of the devices for later exposure/biomarker analysis.
Study focus: Occupational aerosol exposure study linking airport-worker exposures, lung function, and RTube EBC biomarkers.
12. Exhaled breath condensate contains extracellular vesicles that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed
Citation: Mitchell, M. I., Ben-Dov, I. Z., Ye, K., Liu, C., et al. (2024). Exhaled breath condensate contains extracellular vesicles that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed. Journal of Extracellular Vesicles.
RTube use: The authors evaluated whether EBC collected with the RTube device allowed condensation and recovery of exhaled extracellular vesicles, then selectively purified and analyzed miRNA cargo.
Study focus: Extracellular-vesicle and miRNA method study validating RTube EBC as a source of lung-origin vesicular biomarkers.
13. Measurement of human and bovine exhaled breath condensate pH using polyaniline-modified flexible inkjet-printed nanocarbon electrodes
Citation: Jacobs, A. I., Prete, M. C., Lesch, A., Sebio, A. A., et al. (2024). Measurement of human and bovine exhaled breath condensate pH using polyaniline-modified flexible inkjet-printed nanocarbon electrodes. ACS Omega, 9(39), 40841–40856. https://doi.org/10.1021/acsomega.4c05800
RTube use: An RTube device was used for human EBC collection, while a modified collection arrangement was used for bovine breath condensate; pH was measured with flexible inkjet-printed carbon electrodes.
Study focus: Electrochemical sensor study using RTube human EBC for pH measurement and cross-species comparison.
14. A pilot study to detect inflammatory biomarkers of pneumonitis in exhaled breath during chemoradiotherapy for stage III non-small cell lung cancer
Citation: Hughes, R. T., Reno, K. E., Levine, B., Bishop, A. C., et al. (2024). A pilot study to detect inflammatory biomarkers of pneumonitis in exhaled breath during chemoradiotherapy for stage III non-small cell lung cancer. International Journal of Radiation Oncology Biology Physics.
RTube use: EBC and serum were collected at baseline, two weeks, six weeks, and one month post-chemoradiotherapy; EBC was collected using the RTube device to monitor inflammatory biomarkers.
Study focus: Cancer-therapy toxicity pilot study using repeated RTube EBC sampling to detect pneumonitis-associated inflammation.
15. Extraction and characterization of exosomes from the exhaled breath condensate and sputum of lung cancer patients and vulnerable tobacco consumers
Citation: Bano, A., Yadav, P., Sharma, M., Verma, D., et al. (2024). Extraction and characterization of exosomes from the exhaled breath condensate and sputum of lung cancer patients and vulnerable tobacco consumers. Journal of Breath Research.
RTube use: Approximately 320 μL of EBC collected from RTUBE was centrifuged and processed with exosome isolation reagent to characterize exosomal material in lung cancer and tobacco-exposed participants.
Study focus: Lung-cancer exosome study using RTube EBC as a noninvasive liquid-biopsy matrix.
16. Cannabinoids detected in exhaled breath condensate after cannabis use
Citation: Berry, J. L., Brooks-Russell, A., Beuning, C. N., et al. (2024). Cannabinoids detected in exhaled breath condensate after cannabis use. Journal of Breath Research.
RTube use: The study collected EBC as an aqueous breath matrix containing condensed volatile compounds and aerosols, using RTube-based condensate capture to test cannabinoid detection after cannabis use.
Study focus: Breath toxicology study evaluating cannabinoids in RTube-collected EBC.
17. Development and validation of a method for analysis of 25 cannabinoids in oral fluid and exhaled breath condensate
Citation: Swaminathan, M., Tarifa, A., & DeCaprio, A. P. (2024). Development and validation of a method for analysis of 25 cannabinoids in oral fluid and exhaled breath condensate. Analytical and Bioanalytical Chemistry.
RTube use: Participants breathed into a chilled disposable plastic RTube for 5–10 minutes; the sleeve was positioned over the RTube and condensate was recovered for cannabinoid method validation.
Study focus: Analytical method validation for cannabinoid measurement in RTube-collected EBC.
18. Exhaled Breath Condensate Surveillance for Aspergillus in Acute Leukemia: A Pilot Trial
Citation: Bitterman, R., Arora, S., Ng, C. F., Walti, L., et al. (2024). Exhaled breath condensate surveillance for Aspergillus in acute leukemia: A pilot trial. Open Forum Infectious Diseases.
RTube use: The study evaluated Aspergillus droplet-digital PCR in EBC for leukemia patients; the Respiratory Research index places the work within the RTube EBC corpus, with collection used as the noninvasive airway surveillance matrix.
Study focus: Pilot fungal surveillance study testing EBC as a screening sample for Aspergillus in immunocompromised patients.
19. The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study
Citation: Gu, S. Y., Lu, H. W., Bai, J. W., Yang, J. W., Mao, B., Yu, L., et al. (2024). The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: An observational study. Frontiers in Medicine.
RTube use: Disposable RTube exhaled breath condensate collectors were used to minimize cross-contamination and infectious risk while collecting breath samples for VOC-related bronchiectasis assessment.
Study focus: Bronchiectasis breathomics study using RTube collectors to relate VOC/EBC signatures to disease features.
20. A Clinical Breathomics Dataset
Citation: Kuo, P. H., Jhong, Y. C., Kuo, T. C., Hsu, Y. T., Kuo, C. H., et al. (2024). A clinical breathomics dataset. Scientific Data. https://doi.org/10.1038/s41597-024-03052-2
RTube use: Healthy individuals fasted for 8 hours; the RTube aluminum sleeve was precooled at −80 °C for 20 minutes, subjects breathed tidally for 15 minutes, and EBC samples were immediately stored at −80 °C.
Study focus: Open breathomics dataset using standardized RTube EBC collection for metabolomics-method development and QC.
21. Effects of E-cigarettes on the lung and systemic metabolome in people with HIV
Citation: Zaparte, A., Christopher, C. J., Arnold, C., Richey, L., et al. (2024). Effects of e-cigarettes on the lung and systemic metabolome in people with HIV. Metabolites, 14, 434.
RTube use: Participants breathed normally through a cooled RTube to collect EBC; condensate was analyzed with oral and stool metabolomes to assess vaping-associated metabolic changes in people with HIV.
Study focus: Human metabolomics study using RTube EBC to examine e-cigarette effects on lung-associated metabolites.
22. Roles of inflammatory biomarkers in exhaled breath condensates in respiratory clinical fields
Citation: Choi, Y. J., Lee, M. J., Byun, M. K., Park, S., Park, J., et al. (2024). Roles of inflammatory biomarkers in exhaled breath condensates in respiratory clinical fields. Tuberculosis and Respiratory Diseases.
RTube use: Subjects breathed through the RTube mouthpiece and condensate was pushed into the cap with the plunger; EBC inflammatory biomarkers were measured across respiratory clinical contexts.
Study focus: Clinical respiratory biomarker study using standardized RTube EBC handling for inflammatory-marker analysis.
23. A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism
Citation: Gade, I. L., Riddersholm, S. J., et al. (2023). A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism. Journal of Breath Research.
RTube use: The RTube aluminum sleeve was precooled to −80 °C, transported on dry ice, covered with insulation during collection, and used to collect EBC for proteomic pulmonary embolism biomarker discovery.
Study focus: Clinical pulmonary embolism proteomics study using chilled RTube condensate collection.
24. MEASURE: Multiplex Exhaled Breath Condensate — Scanning Using Rapid Electro-Analytics
Citation: Bhide, A., Eldeeb, M. A., Pali, M., Muthukumar, S., & Prasad, S. (2023). MEASURE: Multiplex exhaled breath condensate — scanning using rapid electro-analytics. ACS Sensors, 8(9), 3408–3416. https://doi.org/10.1021/acssensors.3c00693
RTube use: Disposable RTube collector tubes procured from Respiratory Research were used to collect EBC for a multiplex electrochemical assay targeting inflammatory biomarkers.
Study focus: Point-of-care sensor platform study using RTube EBC for rapid multiplex biomarker measurement.
25. Stable COPD picture through exhaled breath condensate, questionnaires and tests: A proof of concept study
Citation: Patsiris, S., Afthinos, A., Augouste, L., Valsami, K., et al. (2023). Stable COPD picture through exhaled breath condensate, questionnaires and tests: A proof of concept study. Pulmonology and Respiratory Journal.
RTube use: EBC was collected with the RTube and analyzed with an Accusizer/FxNano particle counter to relate condensate particle concentration to stable COPD assessment.
Study focus: COPD proof-of-concept study linking RTube EBC particle measurements with clinical questionnaires and tests.
26. Metabolomic analysis identifies differences in energy metabolism in exhaled breath condensate from patients with radiation-induced lung fibrosis
Citation: Pierre-Louis, J., Freeberg, M. A. T., Camus, S. V., et al. (2023). Metabolomic analysis identifies differences in energy metabolism in exhaled breath condensate from patients with radiation-induced lung fibrosis. American Thoracic Society Abstracts.
RTube use: EBC was collected with the RTube as a natural respiratory-tract matrix and analyzed metabolomically to evaluate energy-metabolism differences in radiation-induced lung fibrosis.
Study focus: Radiation-induced lung fibrosis metabolomics study using RTube EBC.
27. Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination
Citation: Shi, M., Han, W., Loudig, O., Shah, C. D., Dobkin, J. B., et al. (2023). Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Scientific Reports, 13, 6620. https://doi.org/10.1038/s41598-023-33698-8
RTube use: Seated subjects were equipped with the RTube system before clinically indicated procedures; condensate was recovered from the device and interrogated by qualitative RT-PCR for a lung-cancer-associated microRNA panel.
Study focus: Case-control lung cancer liquid-biopsy study using RTube EBC microRNA detection.
28. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia
Citation: Course, C. W., Lewis, P. A., Kotecha, S. J., Cousins, M., et al. (2023). Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports.
RTube use: Children underwent respiratory testing with EBC collection using RTube®, and the condensate proteome was characterized before/after inhaler therapy.
Study focus: Pediatric BPD proteomics study using RTube EBC to measure airway protein changes linked to treatment.
29. Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Citation: Rubio, K., Müller, J. M., Mehta, A., Watermann, I., Olchers, T., et al. (2023). Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score. Discover Oncology.
RTube use: Exhaled breath condensates were collected with an RTube device according to Respiratory Research protocols and analyzed for molecular loci contributing to the LC score.
Study focus: Early lung cancer detection study using RTube EBC for molecular marker scoring.
30. Evidence of abnormality in glutathione metabolism in the airways of preterm-born children with a history of bronchopulmonary dysplasia
Citation: Course, C. W., Lewis, P. A., Kotecha, S. J., Cousins, M., et al. (2023). Evidence of abnormality in glutathione metabolism in the airways of preterm-born children with a history of bronchopulmonary dysplasia. Scientific Reports.
RTube use: EBC was collected in a standardized manner using an RTube cooling tube and then subjected to metabolomic analysis focused on glutathione-related airway metabolism.
Study focus: Pediatric BPD metabolomics study using RTube EBC to identify oxidative-stress/metabolic abnormalities.
31. Bacterial microbiota differences in the respiratory tract of children with bronchial asthma
Citation: Bar, K. (2023). Bacterial microbiota differences in the respiratory tract of children with bronchial asthma. Medical University repository.
RTube use: Exhaled breath condensate was collected with the RTube kit and compared with other airway samples to assess bacterial microbiota patterns in children with asthma.
Study focus: Pediatric asthma microbiome study using RTube EBC as a low-biomass respiratory sample.
32. A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection
Citation: Mosquera-Restrepo, S. F., Zuberogoïtia, S., Nigou, J., et al. (2022). A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection. Nature Communications, 13.
RTube use: EBCs were collected using R-tubes from Respiratory Research; the device was used as a noninvasive system to collect and condense expiration components for tuberculosis detection.
Study focus: Tuberculosis diagnostic study using RTube EBC to identify breath-based mycobacterial signatures.
33. Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages
Citation: Marie-Desvergne, C., Dubosson, M., et al. (2022). Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages. Journal of Breath Research.
RTube use: RTubes were washed and validated with blank RTubes filled with ultrapure water after washing; patient EBC elemental/particle loads were compared with pulmonary lavage samples.
Study focus: Method-comparison study evaluating RTube EBC particle/element content against invasive respiratory samples.
34. Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide
Citation: Gholizadeh, A., Black, K., Kipen, H., Laumbach, R., Gow, A., et al. (2022). Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide. RSC Advances.
RTube use: EBC was collected using RTube and Jaeger EcoScreen systems; RTube samples were partitioned for immediate analysis or frozen storage, then tested using reduced graphene oxide sensors.
Study focus: Sensor-development study using RTube EBC for nonprocessed inflammatory-biomarker detection.
35. The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma
Citation: Malinchik, M. A., Gorbacheva, N. N., Belenjuk, V. D., et al. (2022). The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma. Siberian Medical Review.
RTube use: EBC was collected with the RTube Exhaled Breath Condensate Collector and cytokine concentrations were measured in native condensate samples.
Study focus: Pediatric asthma study linking RTube EBC cytokines with cytokine gene polymorphisms.
36. Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis
Citation: Wei, S., Chen, Y.-S., & Shi, Y. (2022). Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis. Frontiers in Cellular and Infection Microbiology, 12, 1008924. https://doi.org/10.3389/fcimb.2022.1008924
RTube use: EBC was collected with a commercially available RTube condenser from Respiratory Research; typical adult tidal-breathing collection was 7–10 minutes, aiming for at least 1000 μL condensate for metabolomic analysis.
Study focus: Pulmonary aspergillosis diagnostic metabolomics study using RTube EBC.
37. A pilot study of total personal exposure to volatile organic compounds among Hispanic female domestic cleaners
Citation: Oyer-Peterson, K., et al. (2022). A pilot study of total personal exposure to volatile organic compounds among Hispanic female domestic cleaners. Journal of Occupational and Environmental Hygiene.
RTube use: Participants provided EBC samples in labeled RTubes, which were used alongside badges and blood sampling to assess personal VOC exposure.
Study focus: Occupational exposure pilot study using RTube EBC as one biological matrix for VOC-related biomonitoring.
38. EBC-SURE: Exhaled Breath Condensate-Scanning Using Rapid Electro-Analytics
Citation: Bhide, A., Pali, M., Muthukumar, S., & Prasad, S. (2022). EBC-SURE: A non-faradaic and non-invasive electrochemical assay to screen for pro-inflammatory biomarkers in exhaled breath condensate. Biosensors and Bioelectronics.
RTube use: Human EBC was collected and analyzed on the EBC-SURE electrochemical platform for trace detection of IL-6 and hs-CRP, with RTube collection identified in the RTube research corpus.
Study focus: Electrochemical point-of-care assay study using EBC for inflammatory biomarker screening.
39. Physical training reduces chronic airway inflammation and mediators of remodeling in asthma
Citation: Moraes-Ferreira, R., Brandão-Rangel, M. A. R., et al. (2022). Physical training reduces chronic airway inflammation and mediators of remodeling in asthma. Oxidative Medicine and Cellular Longevity.
RTube use: EBC collection was performed through the RTube; patients breathed into the RTube before downstream assessment of airway inflammation and remodeling mediators.
Study focus: Asthma intervention study using RTube EBC to track training-related airway inflammatory changes.
40. Exhaled eicosanoid metabolomics suggest oxidized lipids/eicosanoids are detectable in lung cancer cases
Citation: Spivack, S. D., Shi, M., Sadoughi, A., Shah, C., et al. (2022). Exhaled eicosanoid metabolomics suggest oxidized lipids/eicosanoids are detectable in lung cancer cases. American Thoracic Society Abstracts.
RTube use: Clinical subjects performed approximately 15 minutes of tidal breathing to collect about 1.0 mL EBC in the RTube for downstream eicosanoid/oxidized-lipid metabolomics.
Study focus: Lung cancer metabolomics study using RTube EBC for eicosanoid signature discovery.
41. Arginine and its analogs as biomarkers in serum and exhaled breath condensate for diagnosis and monitoring of asthma
Citation: Połomska, J. (2022). Arginine and its analogs as new biomarkers measured in serum and exhaled breath condensate for diagnosis and monitoring of asthma. Medical University repository.
RTube use: Exhaled breath condensate was collected using an RTube device and compared with serum measurements of arginine-pathway analytes in asthma diagnosis and monitoring.
Study focus: Asthma biomarker study using RTube EBC for arginine-metabolism analysis.
42. Extracellular vesicle-derived microbiome obtained from exhaled breath condensate in patients with asthma
Citation: An, J., McDowell, A., Kim, Y. K., & Kim, T. B. (2021). Extracellular vesicle-derived microbiome obtained from exhaled breath condensate in patients with asthma. Annals of Allergy, Asthma & Immunology.
RTube use: EBC samples were collected using RTube from Respiratory Research; extracellular vesicles were isolated from EBC and 16S rDNA was analyzed.
Study focus: Asthma microbiome study using RTube EBC to characterize extracellular-vesicle-associated bacterial DNA.
43. Use of exhaled breath condensate in the diagnosis of SARS-CoV-2 (COVID-19)
Citation: Ryan, D. J., Toomey, S., Madden, S. F., Casey, M., et al. (2021). Use of exhaled breath condensate (EBC) in the diagnosis of SARS-CoV-2 (COVID-19). Thorax.
RTube use: EBC was used as a lower-respiratory-tract sample for SARS-CoV-2 RT-PCR detection; RTube-based collection is identified in the RTube EBC research corpus.
Study focus: COVID-19 diagnostic study testing EBC as a noninvasive sample for viral RNA detection.
44. Putative biomarkers for acute pulmonary embolism in exhaled breath condensate
Citation: Gade, I. L., Schultz, J. G., Brøndum, R. F., Kjærgaard, B., et al. (2021). Putative biomarkers for acute pulmonary embolism in exhaled breath condensate. Journal of Clinical Medicine.
RTube use: In a porcine pulmonary embolism model, the RTube was inserted into the expiratory limb of the ventilator circuit to collect EBC for proteomic biomarker discovery.
Study focus: Preclinical pulmonary embolism study using ventilator-adapted RTube EBC collection.
45. Exhaled breath condensate in acute pulmonary embolism: a porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry
Citation: Gade, I. L., Schultz, J. G., Cehofski, L. J., et al. (2021). Exhaled breath condensate in acute pulmonary embolism: A porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry. Journal of Breath Research.
RTube use: The study used RTube-based condensate collection in ventilated pigs to test how condensing temperature influenced EBC yield and protein analysis feasibility.
Study focus: Methodological porcine PE study validating RTube EBC for mass-spectrometry proteomics.
46. Prediction of potential passive exposure from commercial electronic nicotine delivery systems using exhaled breath analysis and computational fluid dynamic modeling
Citation: Oldham, M. J., Bailey, P. C., Castro, N., Lang, Q., et al. (2021). Prediction of potential passive exposure from commercial electronic nicotine delivery systems using exhaled breath analysis and computational fluid dynamic modeling. Journal of Breath Research.
RTube use: EBC from the RTube and filter samples were extracted for GC/MS analysis of nicotine, propylene glycol, and related ENDS aerosol constituents.
Study focus: E-cigarette exposure study using RTube EBC to characterize passive exposure potential.
47. The differences in oxidative status marker and soluble CD95 in COPD during exacerbation and stable periods
Citation: Soodaeva, S., Kubysheva, N., Klimanov, I., et al. (2021). Differences in oxidative status marker and soluble CD95 in patients with moderate to severe COPD during exacerbation and stable disease. Oxidative Medicine and Cellular Longevity.
RTube use: EBC was collected using RTube following ERS/ATS recommendations; oxidative status markers and soluble CD95 were compared in blood and condensate.
Study focus: COPD biomarker study using RTube EBC to assess oxidative and apoptotic/inflammatory markers.
48. The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD
Citation: Ween, M. P., White, J. B., Tran, H. B., Mukaro, V., Jones, C., et al. (2021). The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD. Scientific Reports.
RTube use: EBC was collected with a commercial collector following manufacturer instructions, identified as RTube, and used alongside bronchoalveolar lavage to assess oxidized lipid biology.
Study focus: COPD immunometabolism study using RTube EBC as a noninvasive comparator to lavage samples.
49. The health effects of wearing facemasks on cardiopulmonary system of healthy young adults: a double-blinded randomized crossover trial
Citation: Jiang, M., Meng, X., Qi, L., Hu, X., Xu, R., Yan, M., Shi, Y., et al. (2021). The health effects of wearing facemasks on cardiopulmonary system of healthy young adults: A double-blinded, randomized crossover trial. International Journal of Hygiene and Environmental Health.
RTube use: EBC was collected at all four visits using a commercially available RTube device following standardized breath-condensate collection procedures.
Study focus: Randomized crossover study using RTube EBC to monitor cardiopulmonary effects of facemask wearing.
50. Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate
Citation: Wu, C. M., Adetona, A., Song, C., Naeher, L., et al. (2020). Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate. Journal of Occupational and Environmental Hygiene.
RTube use: EBC was collected on burn and non-burn days using the RTube breath condensate collection device; RTubes were stored on dry ice immediately after sampling.
Study focus: Wildland firefighter exposure study using RTube EBC to track acute pulmonary responses to smoke.
51. Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate?
Citation: Sauvain, J. J., Edmé, J. L., Wild, P., Suarez, G., et al. (2020). Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate? Journal of Breath Research.
RTube use: The authors checked possible RTube contribution to anion concentration by adding Milli-Q water to RTubes and shaking them before assessing participant EBC anion patterns.
Study focus: Occupational/environmental particle-exposure study using RTube EBC and device-blank controls.
52. Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction
Citation: Nishii, K., Ohashi, K., Tamura, T., et al. (2020). Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction. Oncology Letters.
RTube use: Twenty-one EBC samples were collected using the RTube method and analyzed by droplet digital PCR for EGFR mutations.
Study focus: Lung cancer molecular diagnostics study using RTube EBC for EGFR mutation detection.
53. Measurement of short-chain fatty acids in respiratory samples: keep your assay above the water line
Citation: Yue, M., Kim, J. H., Evans, C. R., Kachman, M., et al. (2020). Measurement of short-chain fatty acids in respiratory samples: Keep your assay above the water line. American Journal of Respiratory and Critical Care Medicine.
RTube use: EBC was acquired with an RTube breath condensate collection device according to manufacturer instructions and ATS/ERS recommendations for respiratory sample comparison.
Study focus: Analytical respiratory chemistry study using RTube EBC for short-chain fatty acid measurement concerns.
54. A randomized controlled pilot study of CPAP for patients with chronic cough and obstructive sleep apnea
Citation: Sundar, K. M., Willis, A. M., Smith, S., Hu, N., Kitt, J. P., & Birring, S. S. (2020). A randomized, controlled, pilot study of CPAP for patients with chronic cough and obstructive sleep apnea. Lung.
RTube use: EBC was obtained with the RTube breath condensate collection system to assess airway inflammation before and after CPAP intervention.
Study focus: Sleep-disordered breathing/chronic cough trial using RTube EBC as an airway inflammation measure.
55. Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: a cross-sectional pilot study
Citation: Terrington, D. L., Kim, J. W., Ravenhill, G., et al. (2020). Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: A cross-sectional pilot study. Journal of Breath Research.
RTube use: Paired serum and EBC samples were collected using RTube under clinical guideline recommendations; soluble IL-2 receptor was measured in condensate and serum.
Study focus: Sarcoidosis pilot biomarker study using RTube EBC for local airway immune-marker assessment.
56. Characterization of exhaled breath condensate non-exchangeable hydrogen functional types and lung function of wildland firefighters
Citation: Nelson, J., Chalbot, M. C. G., Pavicevic, Z., et al. (2020). Characterization of exhaled breath condensate non-exchangeable hydrogen functional types and lung function of wildland firefighters. Journal of Breath Research.
RTube use: EBC was collected from wildland firefighters using RTube-based breath-condensate methods to profile condensate chemistry after wildfire smoke exposure.
Study focus: Firefighter smoke-exposure study using RTube EBC for metabolic/chemical profiling and lung-function comparison.
57. Airway hydrogen peroxide during a naturalistic period of sustained psychological stress in individuals with asthma and healthy controls
Citation: Werchan, C. (2020). Airway hydrogen peroxide during a naturalistic period of sustained psychological stress in individuals with asthma and healthy controls. Southern Methodist University thesis.
RTube use: EBC was collected with an RTube device from Respiratory Research and used to measure airway hydrogen peroxide alongside peak-flow and spirometry values.
Study focus: Asthma/stress biomarker study using RTube EBC for hydrogen peroxide measurement.
58. Critical relevance of stochastic effects on low-bacterial-biomass 16S rRNA gene analysis
Citation: Erb-Downward, J. R., Falkowski, N. R., D’Souza, J. C., et al. (2020). Critical relevance of stochastic effects on low-bacterial-biomass 16S rRNA gene analysis. mBio.
RTube use: EBC samples and fresh RTube water controls were obtained using the RTube collection system to test low-biomass microbiome contamination and stochastic signal effects.
Study focus: Microbiome-methodology study using RTube EBC to assess contamination and low-biomass sequence interpretation.
59. Inflammation in children with neuromuscular disorders and sleep disordered breathing
Citation: Trucco, F., Carruthers, E., Davies, J. C., Simonds, A. K., et al. (2020). Inflammation in children with neuromuscular disorders and sleep disordered breathing. Sleep Medicine.
RTube use: Children wore a nose clip and breathed tidally for 10 minutes into an RTube to collect EBC for airway inflammatory marker analysis.
Study focus: Pediatric sleep/neuromuscular disease study using RTube EBC to assess airway inflammation.
60. Noninvasive glucose detection in exhaled breath condensate
Citation: Tankasala, D., & Linnes, J. C. (2019). Noninvasive glucose detection in exhaled breath condensate. Translational Research.
RTube use: The study discussed and used EBC collection approaches including RTube-style condensation for glucose measurement in breath condensate.
Study focus: Noninvasive diagnostic technology study evaluating EBC glucose measurement.
61. cfDNA in exhaled breath condensate and contamination by ambient air: toward volatile biopsies
Citation: Koc, A., Goksel, T., Pelit, L., Korba, K., et al. (2019). cfDNA in exhaled breath condensate (EBC) and contamination by ambient air: Toward volatile biopsies. Journal of Breath Research.
RTube use: The study examined cell-free DNA in EBC and ambient-air contamination issues using commercial breath-condensate collection systems including the RTube.
Study focus: Liquid-biopsy methodology study addressing cfDNA recovery and contamination in RTube-type EBC.
62. Initial discovery of exhaled small polar energetics-related metabolites by GC-MS for lung cancer risk assessment
Citation: Spivack, S., Shi, M. K., Patel, D., Desai, A., Dobkin, J., et al. (2019). Initial discovery of exhaled small polar energetics-related metabolites by GC-MS for lung cancer risk assessment. Journal of Thoracic Oncology.
RTube use: EBC from lung cancer patients and controls was collected noninvasively with a handheld RTube device for GC-MS analysis of small polar metabolites.
Study focus: Lung cancer metabolomics study using RTube EBC for risk-assessment metabolite discovery.
63. Proteome profiling of the exhaled breath condensate after long-term spaceflights
Citation: Kononikhin, A. S., Brzhozovskiy, A. G., et al. (2019). Proteome profiling of the exhaled breath condensate after long-term spaceflights. International Journal of Molecular Sciences.
RTube use: Cosmonaut EBC was collected before and after long-duration spaceflight using breath-condensate methods indexed to RTube/ECoScreen work, enabling proteomic comparison of respiratory condensate.
Study focus: Space medicine proteomics study using EBC to monitor physiological changes after long-term spaceflight.
64. The role of microRNAs in chronic Pseudomonas lung infection in cystic fibrosis
Citation: Fesen, K., Silveyra, P., Fuentes, N., Nicoleau, M., et al. (2019). The role of microRNAs in chronic Pseudomonas lung infection in cystic fibrosis. Respiratory Medicine.
RTube use: EBC was collected from 27 subjects; condensate was recovered from the RTube with a syringe-style plunger and analyzed for microRNAs.
Study focus: Cystic fibrosis study using RTube EBC microRNA analysis in chronic Pseudomonas infection.
65. Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries
Citation: Singh, K. P., Lawyer, G., Muthumalage, T., et al. (2019). Systemic biomarkers in electronic cigarette users: Implications for noninvasive assessment of vaping-associated pulmonary injuries. ERJ Open Research.
RTube use: EBC samples were collected during tidal breathing for 10 minutes using an RTube collection device and analyzed for vaping-related biomarker changes.
Study focus: E-cigarette exposure study using RTube EBC to assess noninvasive biomarkers of pulmonary injury.
66. Low-flow domiciliary oxygen as a mechanism of ongoing oxidative stress
Citation: Stulce, J. M., Biddle, C., & Vacchiano, C. (2019). Low-flow domiciliary oxygen as a mechanism of ongoing oxidative stress. Respiratory Care.
RTube use: EBC was collected from each participant using an RTube device and analyzed for isofuran/oxidative-stress indicators in the context of domiciliary oxygen exposure.
Study focus: COPD/oxygen-therapy study using RTube EBC to measure oxidative stress.
67. Brief report on the detection of the EGFR T790M mutation in exhaled breath condensate from lung cancer patients
Citation: Smyth, R. J., Toomey, S. M., Sartori, A., O’Hanrahan, E., et al. (2018). Brief report on the detection of the EGFR T790M mutation in exhaled breath condensate from lung cancer patients. Journal of Thoracic Oncology.
RTube use: EBC was collected with an RTube breath condensate device with the cooling sleeve at −70 °C; patients breathed into the RTube for downstream EGFR T790M mutation detection.
Study focus: Lung cancer molecular diagnostics study using RTube EBC for resistance-mutation detection.
68. MicroRNAs in exhaled breath condensate and bronchial brushings as biomarkers for early diagnosis of lung cancer
Citation: Pattnaik, B., Chakraborty, S., Bajpai, P., Agrawal, A., et al. (2018). MicroRNAs in exhaled breath condensate and bronchial brushings as biomarkers for early diagnosis of lung cancer. Journal of Thoracic Oncology.
RTube use: Samples were collected from suspected NSCLC patients during outpatient visits using RTube, followed by microRNA isolation and analysis.
Study focus: Early lung cancer biomarker study using RTube EBC microRNAs.
69. Proteomic characterization of human exhaled breath condensate
Citation: Lacombe, M., Marie-Desvergne, C., et al. (2018). Proteomic characterization of human exhaled breath condensate. Journal of Breath Research.
RTube use: EBC was obtained noninvasively by condensation of exhaled air using RTube-indexed breath-condensate collection procedures for in-depth proteomic characterization.
Study focus: Human EBC proteomics method study defining protein profiles in RTube-type condensate.
70. Exhaled breath condensate nitrite in premature infants with bronchopulmonary dysplasia
Citation: Yen, E. Y., Weinberger, B. I., Laumbach, R. J., et al. (2018). Exhaled breath condensate nitrite in premature infants with bronchopulmonary dysplasia. Journal of Neonatal-Perinatal Medicine.
RTube use: The RTube was encased at −80 °C, connected into the ventilator circuit, then capped and maintained on dry ice after collection for nitrite measurement.
Study focus: Neonatal BPD study using ventilator-adapted RTube EBC to measure nitrite.
71. Effect of temperature control on the metabolite content in exhaled breath condensate
Citation: Zamuruyev, K. O., Borras, E., Pettit, D. R., Aksenov, A. A., et al. (2018). Effect of temperature control on the metabolite content in exhaled breath condensate. Analytica Chimica Acta.
RTube use: A regular passively cooled RTube and a custom thermoelectric RTube setup were compared to determine how condensation temperature changes metabolite content in EBC.
Study focus: EBC method study using RTube to test temperature effects on metabolite recovery.
72. Determination of thiocyanate in exhaled breath condensate
Citation: Chandler, J. D., Horati, H., Walker, D. I., Pagliano, E., et al. (2018). Determination of thiocyanate in exhaled breath condensate. Free Radical Biology and Medicine.
RTube use: Donors breathed steadily for 10 minutes into an RTube with an insulated aluminum sleeve precooled to −80 °C; EBC thiocyanate was measured analytically.
Study focus: Analytical biomarker study using RTube EBC for thiocyanate detection.
73. Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients
Citation: Bhimji, A., Bhaskaran, A., Singer, L. G., Kumar, D., et al. (2018). Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients. Clinical Microbiology and Infection.
RTube use: Standardized EBC collection used a refrigerated RTube condenser; neat and diluted EBC galactomannan results were compared with BAL fluid.
Study focus: Invasive aspergillosis diagnostic study using RTube EBC as a noninvasive comparator to BAL.
74. Evaluation of a new method for the collection and measurement of 8-isoprostane in exhaled breath for nanoparticle exposure biomonitoring
Citation: Marie-Desvergne, C., Dubosson, M., et al. (2018). Evaluation of a new method for the collection and measurement of 8-isoprostane in exhaled breath for future application in nanoparticle exposure biomonitoring. Journal of Breath Research.
RTube use: The new method was evaluated and compared with RTube collection for exhaled breath condensate 8-isoprostane biomonitoring.
Study focus: Occupational biomonitoring methods study comparing RTube EBC with alternate collection for oxidative stress measurement.
75. Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics
Citation: Kilk, K., Aug, A., Ottas, A., Soomets, U., Altraja, S., et al. (2018). Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics. International Journal of Molecular Sciences.
RTube use: EBC was collected using single-use RTube sets and integrated with blood metabolomics and clinical characteristics for COPD phenotyping.
Study focus: COPD metabolomics study using RTube EBC for molecular phenotyping.
76. Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls
Citation: Kurti, S. P., Emerson, S. R., Smith, J. R., et al. (2018). Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls. Applied Physiology, Nutrition, and Metabolism.
RTube use: Participants breathed into an RTube, yielding about 1.0–1.5 mL of EBC; samples were plunged from RTubes, aliquoted, and analyzed for 8-isoprostane responses.
Study focus: Exercise physiology study using RTube EBC to measure airway oxidative stress.
77. Soluble HLA-I and HLA-II molecules are potential prognostic markers of progression of systemic and local inflammation in COPD
Citation: Kubysheva, N., Soodaeva, S., Novikov, V., Eliseeva, T., et al. (2018). Soluble HLA-I and HLA-II molecules are potential prognostic markers of progression of systemic and local inflammation in patients with COPD. Disease Markers.
RTube use: EBC was collected within 20 minutes after mouth rinsing using the RTube system; serum and condensate were stored for soluble HLA measurements.
Study focus: COPD inflammatory-progression study using RTube EBC to quantify soluble immune markers.
78. Clinical significance of leptin in exhaled breath condensate before and after OSAHS surgery
Citation: Liang, W., Wu, P., Zhu, H., Deng, Y., Guan, Y., et al. (2018). Clinical significance of leptin in exhaled breath condensate before and after OSAHS surgery. New Medicine.
RTube use: EBC was collected with an RTube EBC collector from Respiratory Research according to breath-condensate recommendations, then leptin was measured around OSAHS surgery.
Study focus: Sleep apnea surgery study using RTube EBC leptin as a disease/severity biomarker.
79. Exhaled breath condensate metabolome clusters for endotype discovery in asthma
Citation: Sinha, A., Desiraju, K., Aggarwal, K., Kutum, R., et al. (2017). Exhaled breath condensate metabolome clusters for endotype discovery in asthma. Journal of Translational Medicine.
RTube use: EBC was collected using RTubes from Respiratory Research, designed to collect condensate without contamination; samples were immediately stored at −80 °C for metabolomics.
Study focus: Asthma endotyping study using RTube EBC metabolomic clustering.
80. Correlation between TNF-α and IL-1β in exhaled breath condensate and pulmonary function
Citation: Lin, X., Fan, Y., Wang, X., Chi, M., Li, X., Zhang, X., et al. (2017). Correlation between tumor necrosis factor-α and interleukin-1β in exhaled breath condensate and pulmonary function. American Journal of the Medical Sciences.
RTube use: EBC was collected with an RTube condensate collector; approximately 2 mL was collected and immediately stored at −80 °C for TNF-α and IL-1β analysis.
Study focus: Respiratory inflammation study using RTube EBC cytokines and lung-function correlations.
81. Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children
Citation: Kwak, B. O., & Park, Y. M. (2017). Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children. Allergy, Asthma & Respiratory Disease.
RTube use: EBC samples were collected with RTube at baseline and follow-up points, and leukotriene E4 was used to assess inflammation and treatment effect.
Study focus: Pediatric allergic rhinitis study using RTube EBC leukotriene E4 as a noninvasive biomarker.
82. Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate
Citation: Cruickshank-Quinn, C., Armstrong, M., Powell, R., et al. (2017). Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate. Respiratory Research.
RTube use: RTubes were used with controlled collection/testing arrangements; the study compared recovery and contamination behavior for asthma-related molecules in plastic versus glass/device configurations.
Study focus: EBC methodology study evaluating RTube recovery and salivary-contamination concerns for asthma biomarker work.
83. The novel detection of EGFR-T790M mutations in exhaled breath condensate
Citation: Smyth, R., Toomey, S., Sartori, A., O’Hanrahan, E., Cuffe, S., et al. (2017). The novel detection of EGFR-T790M mutations in exhaled breath condensate. Journal of Clinical Oncology/ASCO Abstracts.
RTube use: EBC samples were collected using the RTube device and compared with plasma for EGFR-T790M mutation detection.
Study focus: Lung cancer resistance-mutation study using RTube EBC as a noninvasive molecular sample.
84. Aspergillus galactomannan detection in exhaled breath condensate for the diagnosis of invasive aspergillosis in lung transplant recipients
Citation: Bhimji, A., Bhaskaran, A., Singer, L. G., Kumar, D., et al. (2017). Aspergillus galactomannan detection in exhaled breath condensate for the diagnosis of invasive aspergillosis in lung transplant recipients. Journal of Heart and Lung Transplantation.
RTube use: Standardized EBC was collected using a refrigerated RTube condenser, with BAL performed immediately afterward; EBC galactomannan was analyzed neat and diluted.
Study focus: Transplant infectious-disease study using RTube EBC for Aspergillus diagnostic testing.
85. Validation of nanoparticle tracking analysis to measure pulmonary nanoparticle content: size distribution in exhaled breath condensate depends on occupational exposure
Citation: Sauvain, J. J., Suarez, G., Edmé, J. L., et al. (2017). Validation of nanoparticle tracking analysis to measure pulmonary nanoparticle content: The size distribution in exhaled breath condensate depends on occupational exposure. Journal of Breath Research.
RTube use: The study verified RTubes and microtubes for particle contamination by adding filtered water and shaking before analyzing EBC nanoparticle distributions.
Study focus: Occupational exposure method study using RTube EBC for nanoparticle tracking analysis.
86. Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD
Citation: Lin, X., Wu, Z., Fan, Y., Chi, M., et al. (2017). Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD. Molecular Medicine Reports.
RTube use: EBC was collected with an RTube condenser for 10–15 minutes, yielding 1–3 mL; condensate was removed to cryovials and stored at −80 °C before surfactant-protein analysis.
Study focus: Lung cancer/COPD study using RTube EBC surfactant proteins and lung-function correlations.
87. Exhaled breath condensate acidification occurs during surgery for abdominal cancer
Citation: Mahairidou, A., Rodopoulou, S., Tomos, I., et al. (2017). Exhaled breath condensate acidification occurs during surgery for abdominal cancer. Anticancer Research.
RTube use: About 1.0–1.5 mL EBC was collected; during mechanical ventilation, the RTube was inserted early into the expiratory limb to obtain adequate condensate volume.
Study focus: Perioperative oncology study using RTube EBC pH/acidification as an intraoperative lung-injury marker.
88. EGEA collection: a biobank devoted to asthma and asthma-related phenotypes
Citation: Nadif, R., Bouzigon, E., et al. (2017). EGEA collection: A biobank devoted to asthma and asthma-related phenotypes. Open Journal of Bioresources.
RTube use: EBC was collected with an RTube under standardized procedures as part of the EGEA asthma-related phenotype biobank, alongside FeNO and other phenotyping measures.
Study focus: Asthma biobank study using standardized RTube EBC collection for future biomarker research.
89. The association of e-cigarette use with exposure to nickel and chromium: a preliminary study of non-invasive biomarkers
Citation: Aherrera, A., Olmedo, P., Grau-Perez, M., Tanda, S., et al. (2017). The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers. Environmental Research.
RTube use: Urine, saliva, and EBC were collected; EBC used an RTube system for 10 minutes to assess nickel and chromium exposure in e-cigarette users.
Study focus: E-cigarette metal-exposure study using RTube EBC as a noninvasive biomonitoring matrix.
90. Mycoplasma pneumoniae and health outcomes in children with asthma
Citation: Wood, P. R., Kampschmidt, J. C., Dube, P. H., et al. (2017). Mycoplasma pneumoniae and health outcomes in children with asthma. Annals of Allergy, Asthma & Immunology.
RTube use: EBC was collected using the RTube and measured for pH with a micro pH electrode as part of asthma outcome assessment.
Study focus: Pediatric asthma infection/outcomes study using RTube EBC pH.
91. Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study
Citation: Andrianjafimasy, M., Zerimech, F., Akiki, Z., et al. (2017). Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study. European Respiratory Journal.
RTube use: EBC was collected using RTube according to a standardized method; the RTube was rinsed with deionized water and dried before participant collection.
Study focus: Asthma epidemiology study using RTube EBC oxidative-stress biomarkers.
92. Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates
Citation: Dierschke, K., Isaxon, C., Andersson, U. B. K., et al. (2017). Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates. International Archives of Occupational and Environmental Health.
RTube use: Participants breathed into an RTube cooled to −25 °C; condensate was allocated for leukotriene B4 and other inflammatory marker assays after welding-fume exposure.
Study focus: Controlled occupational exposure study using RTube EBC to assess nanoparticle-induced airway inflammation.
93. Effects of dietary nitrate on respiratory physiology at high altitude: Results from the Xtreme Alps study
Citation: Cumpstey, A. F., Hennis, P. J., Gilbert-Kawai, E. T., et al. (2017). Effects of dietary nitrate on respiratory physiology at high altitude: Results from the Xtreme Alps study. Nitric Oxide.
RTube use: EBC nitrite measurements were collected as part of the high-altitude nitrate intervention protocol; the RTube corpus identifies breath-condensate collection in this study.
Study focus: High-altitude physiology study using EBC nitrite to assess respiratory effects of dietary nitrate.
94. Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males
Citation: Kurti, S. P., Emerson, S. R., Rosenkranz, S. K., Teeman, C. S., et al. (2017). Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males. Nutrition Research.
RTube use: After 10 minutes of collection, roughly 1.5 mL EBC was obtained and immediately frozen at −60 °C in RTubes; exhaled 8-isoprostane was analyzed in triplicate.
Study focus: Nutrition/oxidative-stress study using RTube EBC to measure meal-linked airway oxidative changes.
95. Serum sST2 levels predict severe exacerbation of asthma: a potential implication for neutrophilic asthma
Citation: Watanabe, M., Nakamoto, K., Sada, M., Inui, T., et al. (2017). Serum sST2 levels predict severe exacerbation of asthma: A potential implication for neutrophilic asthma. American Thoracic Society Abstracts.
RTube use: Airway oxidative stress was assessed by obtaining EBC using an RTube and measuring hydrogen peroxide levels.
Study focus: Asthma exacerbation biomarker study pairing serum sST2 with RTube EBC hydrogen peroxide.
96. Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler
Citation: Zamuruyev, K. O., Aksenov, A. A., et al. (2016). Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler. Journal of Breath Research.
RTube use: The standard RTube was used as the comparator benchmark; the paper describes RTube condensation starting near −54 °C and warming toward 0 °C during a 10-minute collection, affecting volume and reproducibility.
Study focus: Breath-metabolomics methodology study benchmarking an optimized sampler against RTube.
97. Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate
Citation: Mehta, A., Cordero, J., Dobersch, S., et al. (2016). Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate. EMBO Molecular Medicine.
RTube use: EBC collection was performed using the RTube and published EBC guidelines; condensate RNA/transcript isoforms were analyzed for lung-cancer diagnosis.
Study focus: Molecular lung cancer diagnostic study using RTube EBC for transcript isoform detection.
98. Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate
Citation: Marie-Desvergne, C., Dubosson, M., Touri, L., et al. (2016). Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate. Journal of Breath Research.
RTube use: One RTube out of every 50 was reserved as a blank; blank RTubes were compared with participant EBC to quantify background particles and metal contamination.
Study focus: Occupational airport-exposure study using RTube EBC with device blanks for nanoparticle/metal biomonitoring.
99. A method for the preservation and determination of welding fume nanoparticles in exhaled breath condensate
Citation: Gschwind, S., Graczyk, H., Günther, D., et al. (2016). A method for the preservation and determination of welding fume nanoparticles in exhaled breath condensate. Environmental Science: Processes & Impacts.
RTube use: EBC was used as the preserved nanoparticle matrix for occupational exposure analysis; the study appears in the RTube EBC corpus and developed preservation/quantification methods for welding-fume nanoparticles.
Study focus: Occupational nanoparticle exposure methodology using EBC collected in RTube-linked workflows.
100. The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts
Citation: Fedorchenko, K. Y., Ryabokon, A. M., Kononikhin, A. S., et al. (2016). The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts. Russian Chemical Bulletin.
RTube use: Cosmonaut EBC was collected before and after space flight for protein-composition analysis, with the RTube index identifying the work within the RTube breath-condensate corpus.
Study focus: Space-medicine proteomics study using EBC to monitor respiratory protein shifts after spaceflight.